Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 2782179..2782781 | Replicon | chromosome |
Accession | NZ_CP050998 | ||
Organism | Escherichia coli O39:NM str. F8704-2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9XIS6 |
Locus tag | P411_RS14190 | Protein ID | WP_000897305.1 |
Coordinates | 2782470..2782781 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | P411_RS14185 | Protein ID | WP_000356397.1 |
Coordinates | 2782179..2782469 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P411_RS14160 (2777744) | 2777744..2778379 | + | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
P411_RS14165 (2778376) | 2778376..2779305 | + | 930 | WP_000027708.1 | formate dehydrogenase accessory protein FdhE | - |
P411_RS14170 (2779704) | 2779704..2780684 | + | 981 | WP_000399648.1 | IS110-like element IS621 family transposase | - |
P411_RS14175 (2780914) | 2780914..2781156 | - | 243 | WP_001086388.1 | protein YiiF | - |
P411_RS14180 (2781375) | 2781375..2781593 | - | 219 | WP_001295676.1 | CopG family transcriptional regulator | - |
P411_RS14185 (2782179) | 2782179..2782469 | - | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
P411_RS14190 (2782470) | 2782470..2782781 | - | 312 | WP_000897305.1 | hypothetical protein | Toxin |
P411_RS14195 (2783010) | 2783010..2783918 | + | 909 | WP_001299484.1 | alpha/beta hydrolase | - |
P411_RS14200 (2783982) | 2783982..2784923 | - | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
P411_RS14205 (2784968) | 2784968..2785405 | - | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
P411_RS14210 (2785402) | 2785402..2786274 | - | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
P411_RS14215 (2786268) | 2786268..2786867 | - | 600 | WP_001295269.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 2779704..2780684 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12190.19 Da Isoelectric Point: 9.7791
>T153483 WP_000897305.1 NZ_CP050998:c2782781-2782470 [Escherichia coli O39:NM str. F8704-2]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T153483 NZ_CP066925:355411-355563 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCTGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCTGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT153483 WP_000356397.1 NZ_CP050998:c2782469-2782179 [Escherichia coli O39:NM str. F8704-2]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT153483 NZ_CP066925:355640-355774 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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