Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5828556..5829088 Replicon chromosome
Accession NZ_CP050975
Organism Streptomyces sp. RPA4-2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HEP85_RS25880 Protein ID WP_168530032.1
Coordinates 5828834..5829088 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HEP85_RS25875 Protein ID WP_168530031.1
Coordinates 5828556..5828837 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP85_RS25855 5824508..5825557 + 1050 WP_168530028.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
HEP85_RS25860 5825587..5826336 + 750 WP_168530029.1 ROK family protein -
HEP85_RS25865 5826411..5827022 - 612 WP_211118061.1 hypothetical protein -
HEP85_RS25870 5827198..5828286 + 1089 WP_168530030.1 redox-regulated ATPase YchF -
HEP85_RS25875 5828556..5828837 + 282 WP_168530031.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HEP85_RS25880 5828834..5829088 + 255 WP_168530032.1 Txe/YoeB family addiction module toxin Toxin
HEP85_RS25885 5829355..5830464 - 1110 WP_168530033.1 pyridoxal-phosphate dependent enzyme -
HEP85_RS25890 5830584..5831936 + 1353 WP_168530034.1 DUF4190 domain-containing protein -
HEP85_RS25895 5832084..5832836 + 753 WP_168530035.1 GntR family transcriptional regulator -
HEP85_RS25900 5833190..5833372 + 183 WP_168530036.1 SPOR domain-containing protein -
HEP85_RS25905 5833437..5833811 + 375 Protein_5067 (deoxy)nucleoside triphosphate pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10112.60 Da        Isoelectric Point: 8.4461

>T153471 WP_168530032.1 NZ_CP050975:5828834-5829088 [Streptomyces sp. RPA4-2]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVRRDPFSGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T153471 NZ_CP066918:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10027.24 Da        Isoelectric Point: 5.6293

>AT153471 WP_168530031.1 NZ_CP050975:5828556-5828837 [Streptomyces sp. RPA4-2]
VSITASEARKELFPLIKKVNENHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGHINVSEREL
IDPDSADAGAGTA

Download         Length: 282 bp

>AT153471 NZ_CP066918:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References