153454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1641125..1641639 Replicon chromosome
Accession NZ_CP050919
Organism Limosilactobacillus fermentum strain HFD1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A806T892
Locus tag HCY95_RS08285 Protein ID WP_021350110.1
Coordinates 1641125..1641388 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag HCY95_RS08290 Protein ID WP_003684069.1
Coordinates 1641385..1641639 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCY95_RS08270 1637051..1637737 + 687 WP_168183601.1 hypothetical protein -
HCY95_RS08275 1638259..1639380 + 1122 WP_187350366.1 PTS sugar transporter subunit IIC -
HCY95_RS08280 1639530..1640750 + 1221 WP_168183499.1 IS256 family transposase -
HCY95_RS08285 1641125..1641388 - 264 WP_021350110.1 Txe/YoeB family addiction module toxin Toxin
HCY95_RS08290 1641385..1641639 - 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HCY95_RS08295 1641870..1643220 - 1351 Protein_1581 transposase -
HCY95_RS08300 1643603..1644973 - 1371 WP_003684065.1 FAD-dependent oxidoreductase -
HCY95_RS08305 1645107..1646039 - 933 WP_087908370.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1640747..1654719 13972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10262.99 Da        Isoelectric Point: 10.7050

>T153454 WP_021350110.1 NZ_CP050919:c1641388-1641125 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHNR

Download         Length: 264 bp

>T153454 NZ_CP066914:c483-217 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT153454 WP_003684069.1 NZ_CP050919:c1641639-1641385 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT153454 NZ_CP066914:c691-467 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806T892

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References