Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1479298..1480073 Replicon chromosome
Accession NZ_CP050858
Organism Klebsiella pneumoniae strain SCH6109

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag HC233_RS07335 Protein ID WP_004150910.1
Coordinates 1479588..1480073 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HC233_RS07330 Protein ID WP_004150912.1
Coordinates 1479298..1479591 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC233_RS07310 1474506..1475108 - 603 WP_002916735.1 short chain dehydrogenase -
HC233_RS07315 1475206..1476117 + 912 WP_105910473.1 LysR family transcriptional regulator -
HC233_RS07320 1476118..1477266 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
HC233_RS07325 1477277..1478653 - 1377 WP_004217775.1 cystathionine beta-synthase -
HC233_RS07330 1479298..1479591 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HC233_RS07335 1479588..1480073 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
HC233_RS07340 1480777..1481370 + 594 WP_004188553.1 hypothetical protein -
HC233_RS07345 1481467..1481683 + 217 Protein_1391 transposase -
HC233_RS07350 1482308..1483378 - 1071 WP_045337777.1 ParA family protein -
HC233_RS07355 1483521..1483859 - 339 WP_045337778.1 hypothetical protein -
HC233_RS07360 1483884..1484435 - 552 WP_045337779.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1481467..1481619 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T153368 WP_004150910.1 NZ_CP050858:1479588-1480073 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T153368 NZ_CP066888:c52009-51593 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT153368 WP_004150912.1 NZ_CP050858:1479298-1479591 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT153368 NZ_CP066888:c52236-52006 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References