Detailed information of TA system TA153358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2637939..2638447
• Replicon: chromosome
• Accession: NZ_CP050855
• Organism: Serratia symbiotica strain CWBI-2.3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SYMBAF_RS13210
• Protein ID: WP_082026805.1
• Coordinates: 2637939..2638205 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: E9CKE8
• Locus tag: SYMBAF_RS13215
• Protein ID: WP_006708173.1
• Coordinates: 2638202..2638447 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYMBAF_RS13185	2633268..2634689	-	1422	WP_040262827.1	sulfate adenylyltransferase subunit CysN	-
SYMBAF_RS13190	2634701..2635609	-	909	WP_040262899.1	sulfate adenylyltransferase subunit CysD	-
SYMBAF_RS13195	2635632..2637062	-	1431	WP_040262825.1	siroheme synthase CysG	-
SYMBAF_RS13200	2637115..2637417	-	303	WP_175576940.1	hypothetical protein	-
SYMBAF_RS13205	2637377..2637835	-	459	WP_040262821.1	hypothetical protein	-
SYMBAF_RS13210	2637939..2638205	-	267	WP_082026805.1	Txe/YoeB family addiction module toxin	Toxin
SYMBAF_RS13215	2638202..2638447	-	246	WP_006708173.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SYMBAF_RS13220	2638514..2638693	-	180	WP_152609008.1	hypothetical protein	-
SYMBAF_RS13225	2638709..2638954	-	246	WP_052447611.1	hypothetical protein	-
SYMBAF_RS13230	2639232..2640149	-	918	WP_040262818.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
SYMBAF_RS13235	2640142..2640915	-	774	WP_040262816.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
SYMBAF_RS13240	2641520..2642800	-	1281	WP_040262814.1	site-specific integrase	-
SYMBAF_RS13245	2643036..2643287	-	252	WP_185899907.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.18 Da
• Isoelectric Point: 10.3823

>T153358 WP_082026805.1 NZ_CP050855:c2638205-2637939 [Serratia symbiotica]
MKIRFTRRAATDFQYWQKNNVKVYERVQLLIKAAHADPFCGIGKPERLRHHKNPALYSRRIDREHRLVYSVTDGELTIIA
CRFHYESL

Nucleotide

• Length: 267 bp

>T153358 NZ_CP066887:355278-355625 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9123.26 Da
• Isoelectric Point: 4.6069

>AT153358 WP_006708173.1 NZ_CP050855:c2638447-2638202 [Serratia symbiotica]
MHALTFTDARKHFAETMQRVSDNAEPVRILRRDAPDVIIIGAHEYDAMVETLHLFSNPVNAAHINASLDELERGDIVEID
V

Nucleotide

• Length: 246 bp

>AT153358 NZ_CP066887:355625-355924 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A068YWA6