Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1797829..1798580 Replicon chromosome
Accession NZ_CP050855
Organism Serratia symbiotica strain CWBI-2.3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SYMBAF_RS08920 Protein ID WP_040265116.1
Coordinates 1797829..1798140 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SYMBAF_RS08925 Protein ID WP_040264960.1
Coordinates 1798137..1798580 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYMBAF_RS08900 1794436..1795350 - 915 WP_040264962.1 D-alanyl-D-alanine endopeptidase -
SYMBAF_RS08905 1795748..1796311 + 564 WP_040264961.1 DedA family protein -
SYMBAF_RS08910 1796506..1796760 + 255 WP_082026916.1 hypothetical protein -
SYMBAF_RS08915 1797030..1797494 + 465 Protein_1749 helix-turn-helix domain-containing protein -
SYMBAF_RS08920 1797829..1798140 + 312 WP_040265116.1 type II toxin-antitoxin system HigB family toxin Toxin
SYMBAF_RS08925 1798137..1798580 + 444 WP_040264960.1 helix-turn-helix domain-containing protein Antitoxin
SYMBAF_RS08930 1798934..1799720 + 787 Protein_1752 HlyD family efflux transporter periplasmic adaptor subunit -
SYMBAF_RS08935 1799780..1800734 + 955 Protein_1753 hypothetical protein -
SYMBAF_RS08940 1800812..1801135 + 324 WP_152609097.1 hypothetical protein -
SYMBAF_RS08945 1801135..1801350 + 216 WP_040264958.1 hypothetical protein -
SYMBAF_RS08950 1801351..1802607 - 1257 WP_040264957.1 enterobactin transporter EntS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(92-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12338.38 Da        Isoelectric Point: 10.3183

>T153353 WP_040265116.1 NZ_CP050855:1797829-1798140 [Serratia symbiotica]
VHVISRQPFNEAAGKYPNSALALLYLMRVLEKKTFNSPDEMKRAIPSLNNFKYRKKWWVIDVFGNTVRLMAFIDFEKQKV
FVKHIATHAEYDKLTKYYREHKE

Download         Length: 312 bp

>T153353 NZ_CP066884:802437-802790 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16059.36 Da        Isoelectric Point: 4.9736

>AT153353 WP_040264960.1 NZ_CP050855:1798137-1798580 [Serratia symbiotica]
MTVATHIDTASAESMIATFANAVKCIPLMTGDKSEAEYNKALELIEYLVDRDELSNPLFEPLAAKITEYENSAPEFEAFN
RRLAEIPTGVAALHTLMDQHGLKAANLIDELGSKSNVSNILSGRRALTVKHIKALASRFNVPADLFI

Download         Length: 444 bp

>AT153353 NZ_CP066884:802266-802436 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References