Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1160018..1160712 Replicon chromosome
Accession NZ_CP050854
Organism Brenneria izadpanahii strain Iran 50

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HC231_RS05135 Protein ID WP_281397389.1
Coordinates 1160308..1160712 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HC231_RS05130 Protein ID WP_027711146.1
Coordinates 1160018..1160311 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC231_RS05105 (HC231_05105) 1155560..1155784 + 225 WP_208230017.1 hypothetical protein -
HC231_RS05110 (HC231_05110) 1155774..1156976 - 1203 WP_208228152.1 IS256 family transposase -
HC231_RS05115 (HC231_05115) 1157136..1157315 - 180 WP_208230018.1 hypothetical protein -
HC231_RS05120 (HC231_05120) 1157736..1158683 + 948 WP_208230019.1 HNH endonuclease -
HC231_RS23835 1158755..1159009 - 255 Protein_1001 integrase -
HC231_RS05125 (HC231_05125) 1159009..1159611 + 603 WP_208231227.1 ubiquinol-cytochrome C chaperone family protein -
HC231_RS05130 (HC231_05130) 1160018..1160311 + 294 WP_027711146.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HC231_RS05135 (HC231_05135) 1160308..1160712 + 405 WP_281397389.1 type II toxin-antitoxin system YafO family toxin Toxin
HC231_RS23840 1161123..1161305 + 183 Protein_1005 hypothetical protein -
HC231_RS05145 (HC231_05145) 1161340..1161972 + 633 Protein_1006 winged helix-turn-helix domain-containing protein -
HC231_RS05150 (HC231_05150) 1162049..1162411 - 363 WP_208230021.1 cupin domain-containing protein -
HC231_RS05155 (HC231_05155) 1162487..1163305 - 819 WP_208230022.1 AraC family transcriptional regulator -
HC231_RS05160 (HC231_05160) 1163872..1164444 + 573 WP_208230023.1 DUF1349 domain-containing protein -
HC231_RS05165 (HC231_05165) 1164512..1165186 - 675 WP_208230024.1 MarC family NAAT transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1146069..1163305 17236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(29-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15544.85 Da        Isoelectric Point: 6.8447

>T153341 WP_281397389.1 NZ_CP050854:1160308-1160712 [Brenneria izadpanahii]
MSIRIFKSALIRQQLSQQELDDLAEDFLSYKKDGVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFK
RTSDQAHLVYCQGAMDPDAYLLIIILKPEAHKMARNNNHMHKIGMMAEAFRMKH

Download         Length: 405 bp

>T153341 NZ_CP066851:c2882740-2882637 [Salmonella enterica subsp. enterica serovar Heidelberg]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10979.44 Da        Isoelectric Point: 4.9167

>AT153341 WP_027711146.1 NZ_CP050854:1160018-1160311 [Brenneria izadpanahii]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTAARFRPSAERLSDIADSG
QKLLQNASDKDLTEFTE

Download         Length: 294 bp

>AT153341 NZ_CP066851:2882635-2882778 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References