Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 330453..331039 Replicon chromosome
Accession NZ_CP050845
Organism Klebsiella pneumoniae strain Bckp206

Toxin (Protein)


Gene name doc Uniprot ID A0A486RB10
Locus tag HC704_RS01565 Protein ID WP_004174007.1
Coordinates 330671..331039 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HC704_RS01560 Protein ID WP_004174006.1
Coordinates 330453..330674 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC704_RS01540 326610..327536 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HC704_RS01545 327533..328810 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HC704_RS01550 328807..329574 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HC704_RS01555 329576..330289 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HC704_RS01560 330453..330674 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HC704_RS01565 330671..331039 + 369 WP_004174007.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HC704_RS01570 331312..332628 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HC704_RS01575 332735..333622 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HC704_RS01580 333619..334464 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HC704_RS01585 334466..335536 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 327533..336273 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13568.97 Da        Isoelectric Point: 8.6410

>T153320 WP_004174007.1 NZ_CP050845:330671-331039 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDLGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T153320 NZ_CP066844:2660247-2660354 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT153320 WP_004174006.1 NZ_CP050845:330453-330674 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT153320 NZ_CP066844:c2660197-2660140 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RB10

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References