Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2406294..2406983 Replicon chromosome
Accession NZ_CP050829
Organism Klebsiella pneumoniae strain Bckp067

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag HC709_RS12085 Protein ID WP_021469727.1
Coordinates 2406294..2406611 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HC709_RS12090 Protein ID WP_040147778.1
Coordinates 2406687..2406983 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC709_RS12055 2401996..2402505 + 510 WP_002906702.1 GNAT family N-acetyltransferase -
HC709_RS12060 2402515..2403441 + 927 WP_004189808.1 amino acid ABC transporter permease -
HC709_RS12065 2403425..2404204 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
HC709_RS12070 2404243..2405094 + 852 WP_014343117.1 transporter substrate-binding domain-containing protein -
HC709_RS12075 2405172..2405789 + 618 WP_004175955.1 glutathione S-transferase family protein -
HC709_RS12080 2405860..2406087 + 228 WP_002906690.1 tautomerase PptA -
HC709_RS12085 2406294..2406611 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC709_RS12090 2406687..2406983 + 297 WP_040147778.1 helix-turn-helix domain-containing protein Antitoxin
HC709_RS12095 2407062..2407508 + 447 WP_004175959.1 hypothetical protein -
HC709_RS12100 2407549..2409165 - 1617 WP_040147777.1 carbohydrate porin -
HC709_RS12105 2409209..2410591 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T153244 WP_021469727.1 NZ_CP050829:2406294-2406611 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

>T153244 NZ_CP066809:2537883-2537990 [Shigella flexneri 3a]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11032.88 Da        Isoelectric Point: 6.4721

>AT153244 WP_040147778.1 NZ_CP050829:2406687-2406983 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMPMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRQPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp

>AT153244 NZ_CP066809:c2537833-2537770 [Shigella flexneri 3a]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure

References