Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 347469..348145 Replicon chromosome
Accession NZ_CP050829
Organism Klebsiella pneumoniae strain Bckp067

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag HC709_RS01615 Protein ID WP_016529833.1
Coordinates 347469..347816 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HC709_RS01620 Protein ID WP_032413101.1
Coordinates 347816..348145 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC709_RS01605 343395..344828 + 1434 WP_002920564.1 glycogen synthase GlgA -
HC709_RS01610 344846..347293 + 2448 WP_102001163.1 glycogen phosphorylase -
HC709_RS01615 347469..347816 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC709_RS01620 347816..348145 + 330 WP_032413101.1 helix-turn-helix transcriptional regulator Antitoxin
HC709_RS01625 348178..349686 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HC709_RS01630 349891..350220 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HC709_RS01635 350271..351101 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HC709_RS01640 351151..351909 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T153232 WP_016529833.1 NZ_CP050829:347469-347816 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T153232 NZ_CP066807:29267-29425 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11921.98 Da        Isoelectric Point: 10.8046

>AT153232 WP_032413101.1 NZ_CP050829:347816-348145 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNLLTGIRAKRKP

Download         Length: 330 bp

>AT153232 NZ_CP066807:29156-29221 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References