Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 256714..257231 Replicon chromosome
Accession NZ_CP050691
Organism Staphylococcus aureus strain PMB196-1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag HCU71_RS01330 Protein ID WP_000113265.1
Coordinates 256714..256980 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HCU71_RS01335 Protein ID WP_000584499.1
Coordinates 256980..257231 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU71_RS01300 252142..252678 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
HCU71_RS01305 252912..253736 - 825 WP_000572038.1 formate/nitrite transporter family protein -
HCU71_RS01310 253953..254135 - 183 WP_000230292.1 hypothetical protein -
HCU71_RS01315 254219..254686 - 468 WP_000153347.1 SRPBCC domain-containing protein -
HCU71_RS01320 254872..256419 - 1548 WP_167780358.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HCU71_RS01325 256608..256679 - 72 Protein_255 hypothetical protein -
HCU71_RS01330 256714..256980 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
HCU71_RS01335 256980..257231 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HCU71_RS01340 257396..257497 - 102 Protein_258 hypothetical protein -
HCU71_RS01345 257504..258103 - 600 WP_000162810.1 DsbA family protein -
HCU71_RS01350 258122..258484 - 363 WP_000819843.1 DUF4467 domain-containing protein -
HCU71_RS01355 258739..259989 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
HCU71_RS01360 260086..260817 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
HCU71_RS01365 260814..261533 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T153105 WP_000113265.1 NZ_CP050691:c256980-256714 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T153105 NZ_CP066756:4380919-4381179 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT153105 WP_000584499.1 NZ_CP050691:c257231-256980 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT153105 NZ_CP066756:4380640-4380900 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References