Detailed information of TA system TA153099

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1773588..1773866
• Replicon: chromosome
• Accession: NZ_CP050690
• Organism: Staphylococcus aureus strain PMB179-1

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HCU70_RS08635
• Protein ID: WP_001802298.1
• Coordinates: 1773588..1773692 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1773688..1773866 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCU70_RS08620	1770384..1771166	+	783	WP_000908174.1	ABC transporter ATP-binding protein	-
HCU70_RS08625	1771234..1772091	+	858	WP_000370931.1	Cof-type HAD-IIB family hydrolase	-
HCU70_RS08630	1772750..1772908	-	159	WP_001792784.1	hypothetical protein	-
HCU70_RS08635	1773588..1773692	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1773688..1773866	-	179	-	-	Antitoxin
HCU70_RS08640	1774500..1776146	+	1647	WP_000277718.1	IS1182 family transposase	-
HCU70_RS08645	1776175..1777266	-	1092	WP_000495672.1	hypothetical protein	-
HCU70_RS08650	1777532..1778512	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
HCU70_RS08655	1778514..1778834	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1774500..1776146	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T153099 WP_001802298.1 NZ_CP050690:1773588-1773692 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T153099 NZ_CP066756:2946553-2946660 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT153099 NZ_CP050690:c1773866-1773688 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin