153097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1518560..1519077 Replicon chromosome
Accession NZ_CP050690
Organism Staphylococcus aureus strain PMB179-1

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HCU70_RS07310 Protein ID WP_000113262.1
Coordinates 1518811..1519077 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HCU70_RS07305 Protein ID WP_000584499.1
Coordinates 1518560..1518811 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU70_RS07275 1514258..1514977 + 720 WP_000479576.1 amino acid ABC transporter permease -
HCU70_RS07280 1514974..1515705 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
HCU70_RS07285 1515802..1517052 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
HCU70_RS07290 1517307..1517669 + 363 WP_000819843.1 DUF4467 domain-containing protein -
HCU70_RS07295 1517688..1518287 + 600 WP_000162810.1 DsbA family protein -
HCU70_RS07300 1518294..1518395 + 102 Protein_1427 hypothetical protein -
HCU70_RS07305 1518560..1518811 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HCU70_RS07310 1518811..1519077 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HCU70_RS07315 1519371..1520924 + 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HCU70_RS07320 1521110..1521577 + 468 WP_000153344.1 SRPBCC domain-containing protein -
HCU70_RS07325 1521664..1521846 + 183 WP_000079142.1 hypothetical protein -
HCU70_RS07330 1522063..1522887 + 825 WP_000572040.1 formate/nitrite transporter family protein -
HCU70_RS07335 1523121..1523657 + 537 WP_167774981.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T153097 WP_000113262.1 NZ_CP050690:1518811-1519077 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T153097 NZ_CP066756:c2634133-2633957 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT153097 WP_000584499.1 NZ_CP050690:1518560-1518811 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT153097 NZ_CP066756:c2633911-2633495 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References