153094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1461756..1462279 Replicon chromosome
Accession NZ_CP050690
Organism Staphylococcus aureus strain PMB179-1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag HCU70_RS07035 Protein ID WP_000074045.1
Coordinates 1462013..1462279 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag HCU70_RS07030 Protein ID WP_000587619.1
Coordinates 1461756..1462013 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU70_RS07005 1456837..1458030 + 1194 WP_000675406.1 MFS transporter -
HCU70_RS07010 1458254..1459003 - 750 WP_000072464.1 hypothetical protein -
HCU70_RS07015 1459197..1460774 + 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
HCU70_RS07020 1460942..1461397 - 456 WP_000732082.1 DUF1307 domain-containing protein -
HCU70_RS07030 1461756..1462013 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HCU70_RS07035 1462013..1462279 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
HCU70_RS07040 1462635..1463711 + 1077 WP_001076673.1 M42 family metallopeptidase -
HCU70_RS07045 1463959..1464621 + 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
HCU70_RS07050 1464614..1465390 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
HCU70_RS07055 1465786..1466973 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T153094 WP_000074045.1 NZ_CP050690:1462013-1462279 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T153094 NZ_CP066756:1034580-1034915 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT153094 WP_000587619.1 NZ_CP050690:1461756-1462013 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT153094 NZ_CP066756:1034332-1034580 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References