Detailed information of TA system TA153053

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2279362..2279620
• Replicon: chromosome
• Accession: NZ_CP050646
• Organism: Escherichia coli strain PapM-36-2

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: G6008_RS10975
• Protein ID: WP_000809168.1
• Coordinates: 2279468..2279620 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2279362..2279419 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6008_RS10955	2274410..2275741	+	1332	Protein_2153	fimbria/pilus outer membrane usher protein	-
G6008_RS10960	2275754..2276712	+	959	Protein_2154	fimbrial family protein	-
G6008_RS10965	2276751..2277650	-	900	WP_001300855.1	transcriptional activator NhaR	-
G6008_RS10970	2277716..2278882	-	1167	WP_000681368.1	Na+/H+ antiporter NhaA	-
-	2279362..2279419	-	58	-	-	Antitoxin
G6008_RS10975	2279468..2279620	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
G6008_RS10980	2279724..2280854	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
G6008_RS10985	2280943..2282859	-	1917	WP_000516135.1	molecular chaperone DnaK	-
G6008_RS10990	2283236..2283640	+	405	WP_000843559.1	DUF2541 family protein	-
G6008_RS10995	2283666..2284379	+	714	WP_001102379.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T153053 WP_000809168.1 NZ_CP050646:2279468-2279620 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T153053 NZ_CP066750:c13238-12963 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT153053 NZ_CP050646:c2279419-2279362 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin