Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 143176..143678 Replicon chromosome
Accession NZ_CP050646
Organism Escherichia coli strain PapM-36-2

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G6008_RS00745 Protein ID WP_000767829.1
Coordinates 143424..143678 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G6008_RS00740 Protein ID WP_001259255.1
Coordinates 143176..143427 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6008_RS00715 138354..139421 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
G6008_RS00720 139421..140491 - 1071 WP_032241632.1 histidinol-phosphate transaminase -
G6008_RS00725 140488..141792 - 1305 WP_167778705.1 histidinol dehydrogenase -
G6008_RS00730 141798..142697 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
G6008_RS00735 142843..142893 - 51 WP_001364200.1 his operon leader peptide -
G6008_RS00740 143176..143427 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G6008_RS00745 143424..143678 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G6008_RS00750 143761..144585 + 825 WP_000754749.1 SDR family oxidoreductase -
G6008_RS00755 144631..145560 + 930 WP_000803351.1 LysR family transcriptional regulator -
G6008_RS00760 145775..145837 + 63 WP_010723108.1 membrane protein YoeI -
G6008_RS00765 145827..147185 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G6008_RS00770 147364..148422 + 1059 WP_000492346.1 transport protein YeeE -
G6008_RS00775 148436..148663 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T153039 WP_000767829.1 NZ_CP050646:143424-143678 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T153039 NZ_CP066748:3028606-3028713 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT153039 WP_001259255.1 NZ_CP050646:143176-143427 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT153039 NZ_CP066748:c3028553-3028492 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References