Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2377908..2378422 Replicon chromosome
Accession NZ_CP050522
Organism Streptomyces coelicolor strain M1154/pAMX4/pGP1416

Toxin (Protein)


Gene name yoeB Uniprot ID Q9Z4V8
Locus tag HCU77_RS10945 Protein ID WP_003976577.1
Coordinates 2378168..2378422 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q9Z4V7
Locus tag HCU77_RS10940 Protein ID WP_003976578.1
Coordinates 2377908..2378171 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU77_RS10930 2373740..2374609 + 870 WP_003976581.1 phosphatase PAP2 family protein -
HCU77_RS10935 2374735..2377734 - 3000 WP_011028215.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
HCU77_RS10940 2377908..2378171 + 264 WP_003976578.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HCU77_RS10945 2378168..2378422 + 255 WP_003976577.1 Txe/YoeB family addiction module toxin Toxin
HCU77_RS10950 2378485..2378931 + 447 WP_003976576.1 VOC family protein -
HCU77_RS10955 2378954..2380723 - 1770 WP_037666705.1 NAD+ synthase -
HCU77_RS10960 2380806..2381432 - 627 WP_011028217.1 DUF305 domain-containing protein -
HCU77_RS10965 2381429..2382097 - 669 WP_011028218.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9954.26 Da        Isoelectric Point: 9.7377

>T153013 WP_003976577.1 NZ_CP050522:2378168-2378422 [Streptomyces coelicolor]
VRITFTSHGWEDYVHWAESDRKVTKRINRLIADIARDPFKGVGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDQLVIVQA
RYHY

Download         Length: 255 bp

>T153013 NZ_CP066721:c1831779-1831672 [Staphylococcus xylosus]
GTGGTTTCAATTGTAGAAGCGCTACACTTAATGTTAGGTTTCGGTACTTTCATCGTTACCTTATTAGGTTTAGTTATCGC
AATTGTTAAATTAAGCCATAAAAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9692.69 Da        Isoelectric Point: 4.4149

>AT153013 WP_003976578.1 NZ_CP050522:2377908-2378171 [Streptomyces coelicolor]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGDATEHDLI
DPDAERA

Download         Length: 264 bp

>AT153013 NZ_CP066721:1831550-1831682 [Staphylococcus xylosus]
ATAGATAGAAAAAGGGCAACACACATAAGTGTATCGCCCCAGTGAGCCCGTTAAAAAGACGGTGGCTAGTTACTAATAAT
TATCAAAAAATAATCATCGAAACCGGCCAAAGTTAGCGATGGTTATTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9Z4V8

Antitoxin

Source ID Structure
AlphaFold DB Q9Z4V7

References