Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4321587..4322244 Replicon chromosome
Accession NZ_CP050520
Organism Enterobacter sp. DNB-S2

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag HB664_RS20805 Protein ID WP_033146338.1
Coordinates 4321587..4321886 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag HB664_RS20810 Protein ID WP_033146339.1
Coordinates 4321897..4322244 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB664_RS20795 (HB664_20815) 4317957..4320155 + 2199 WP_219940153.1 type I secretion system permease/ATPase -
HB664_RS20800 (HB664_20820) 4320166..4321335 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB664_RS20805 (HB664_20825) 4321587..4321886 + 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB664_RS20810 (HB664_20830) 4321897..4322244 + 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
HB664_RS20815 (HB664_20835) 4322289..4322714 + 426 WP_033146340.1 nucleoside triphosphatase NudI -
HB664_RS20820 (HB664_20840) 4322686..4323417 - 732 WP_219940154.1 helix-turn-helix transcriptional regulator -
HB664_RS20825 (HB664_20845) 4323515..4323934 + 420 WP_219940155.1 nuclear transport factor 2 family protein -
HB664_RS20830 (HB664_20850) 4323937..4324455 - 519 WP_069303206.1 hypothetical protein -
HB664_RS20835 (HB664_20855) 4324540..4325721 - 1182 WP_219940156.1 PLP-dependent aminotransferase family protein -
HB664_RS20840 (HB664_20860) 4325742..4326629 - 888 WP_039263431.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T153011 WP_033146338.1 NZ_CP050520:4321587-4321886 [Enterobacter sp. DNB-S2]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T153011 NZ_CP066721:967805-968167 [Staphylococcus xylosus]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTATCACCAGTGCAAGGGTCTGAACAAGGGGGAATTAGACCCGTCGT
TATTATACAAAACGATACTGGTAACAAATATAGTCCTACAGTAATTGTTGCTGCAATTACTGGTAGGATTAATAAAGCTA
AAATACCTACACATGTAGAGATAGAAAAAAGTAAATATAAACTTGATAAAGATTCTGTTATATTGTTAGAACAAATCAGG
ACTTTAGATAAAAATAGGCTAAAGGAAAAATTAACATATCTTTCTGAGAAAAAAATGAAAGAAGTTAATATTGCTATTGA
TATAAGTTTAGGATTACATAATATTAGGAATCATAAATCCTAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT153011 WP_033146339.1 NZ_CP050520:4321897-4322244 [Enterobacter sp. DNB-S2]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp

>AT153011 NZ_CP066721:967638-967808 [Staphylococcus xylosus]
ATGGCAAGTTTTAATCAAAGTAGAAATCATAGTATTGAACAACTATTAAAAGAAGGCTATTCTCAAATGGCTGACTTAAA
TCTCTCCCTTGCAGCAGAAGCCTTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAGTTTACATTAGCTCTAAGAATA
ATAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References