Detailed information of TA system TA152895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 854534..855067
• Replicon: chromosome
• Accession: NZ_CP050449
• Organism: Kocuria sp. KD4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A1E8UH39
• Locus tag: HBK84_RS03950
• Protein ID: WP_035965439.1
• Coordinates: 854813..855067 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HBK84_RS03945
• Protein ID: WP_167318244.1
• Coordinates: 854534..854812 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBK84_RS03925	850272..851192	+	921	WP_167318241.1	DUF3387 domain-containing protein	-
HBK84_RS03930	851179..851928	+	750	WP_167318242.1	M48 family metallopeptidase	-
HBK84_RS03935	852238..852873	-	636	WP_167318243.1	hypothetical protein	-
HBK84_RS03940	853117..854385	+	1269	Protein_768	ATP-binding protein	-
HBK84_RS03945	854534..854812	+	279	WP_167318244.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HBK84_RS03950	854813..855067	+	255	WP_035965439.1	Txe/YoeB family addiction module toxin	Toxin
HBK84_RS03955	855190..855726	+	537	WP_167318245.1	GNAT family N-acetyltransferase	-
HBK84_RS03960	855891..857321	+	1431	WP_167318246.1	anion permease	-
HBK84_RS03965	857410..858159	-	750	WP_167318247.1	succinate dehydrogenase/fumarate reductase iron-sulfur subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-66)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10155.60 Da
• Isoelectric Point: 7.1630

>T152895 WP_035965439.1 NZ_CP050449:854813-855067 [Kocuria sp. KD4]
MRLVWDEAAWEDYTYWQTADRRILKRINLLIDACLREPFEGIGKPEQLKYGARGSWSRRINEEHRLVYLVTGEDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T152895 NZ_CP066564:c485553-485293 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAATTATGCAAGCTTGATAAAGGCATACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTAAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10416.48 Da
• Isoelectric Point: 4.6926

>AT152895 WP_167318244.1 NZ_CP050449:854534-854812 [Kocuria sp. KD4]
MSISASEARKTLFPLIERVNEDQEAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPSNARRLLDAYDRARDGKTQAHELD
RSDESASQTRDV

Nucleotide

• Length: 279 bp

>AT152895 NZ_CP066564:c485774-485553 [Histophilus somni]
ATGGCTATTTCAGTAAGACTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGACT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A1E8UH39