Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 22237..22895 Replicon plasmid pVB11737_1
Accession NZ_CP050392
Organism Acinetobacter baumannii strain VB11737

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HBM80_RS00180 Protein ID WP_000312250.1
Coordinates 22536..22895 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HBM80_RS00175 Protein ID WP_001096429.1
Coordinates 22237..22536 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBM80_RS00135 17261..18541 + 1281 WP_162200943.1 hypothetical protein -
HBM80_RS00140 18646..18903 + 258 WP_000834290.1 hypothetical protein -
HBM80_RS00145 18908..19480 + 573 WP_000443897.1 hypothetical protein -
HBM80_RS00150 19456..19635 + 180 WP_000387630.1 hypothetical protein -
HBM80_RS00155 19652..20281 + 630 WP_000701003.1 hypothetical protein -
HBM80_RS00160 20321..20539 + 219 WP_001043201.1 hypothetical protein -
HBM80_RS00165 20559..21113 + 555 WP_000790084.1 hypothetical protein -
HBM80_RS00170 21163..21699 + 537 WP_000731978.1 hypothetical protein -
HBM80_RS00175 22237..22536 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
HBM80_RS00180 22536..22895 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBM80_RS00185 23096..23662 + 567 WP_000710385.1 hypothetical protein -
HBM80_RS00190 23711..23893 + 183 WP_000373385.1 hypothetical protein -
HBM80_RS00195 23960..24658 + 699 WP_000873188.1 hypothetical protein -
HBM80_RS00200 24797..25180 + 384 WP_000654348.1 hypothetical protein -
HBM80_RS00205 25247..26005 + 759 WP_001053127.1 hypothetical protein -
HBM80_RS00210 27061..27375 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VIa - 1..70712 70712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T152829 WP_000312250.1 NZ_CP050392:c22895-22536 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T152829 NZ_CP066536:40740-40898 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT152829 WP_001096429.1 NZ_CP050392:c22536-22237 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT152829 NZ_CP066536:40629-40694 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References