Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 2754..3405 | Replicon | plasmid pVB82_2 |
Accession | NZ_CP050387 | ||
Organism | Acinetobacter baumannii strain VB82 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A4R0DYU1 |
Locus tag | HBK86_RS21565 | Protein ID | WP_000269907.1 |
Coordinates | 2754..3110 (+) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | HBK86_RS21570 | Protein ID | WP_001140617.1 |
Coordinates | 3103..3405 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HBK86_RS21545 | 1..951 | + | 951 | WP_001205343.1 | replication initiation protein RepM | - |
HBK86_RS21550 | 944..1519 | + | 576 | WP_001096616.1 | helix-turn-helix domain-containing protein | - |
HBK86_RS21555 | 1539..1682 | + | 144 | WP_001125244.1 | hypothetical protein | - |
HBK86_RS21560 | 1867..2070 | - | 204 | WP_000482656.1 | hypothetical protein | - |
HBK86_RS21565 | 2754..3110 | + | 357 | WP_000269907.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HBK86_RS21570 | 3103..3405 | + | 303 | WP_001140617.1 | helix-turn-helix transcriptional regulator | Antitoxin |
HBK86_RS21575 | 3528..3929 | + | 402 | WP_000660211.1 | hypothetical protein | - |
HBK86_RS21580 | 3946..4248 | + | 303 | WP_001081086.1 | hypothetical protein | - |
HBK86_RS21585 | 4313..5053 | - | 741 | WP_031380848.1 | DUF3800 domain-containing protein | - |
HBK86_RS21590 | 5364..5750 | + | 387 | WP_001986792.1 | helix-turn-helix domain-containing protein | - |
HBK86_RS21595 | 5793..5957 | - | 165 | WP_162216716.1 | hypothetical protein | - |
HBK86_RS21600 | 5960..6331 | - | 372 | WP_005174618.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..7540 | 7540 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13488.42 Da Isoelectric Point: 5.7172
>T152824 WP_000269907.1 NZ_CP050387:2754-3110 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYTEMLAIADQQYELHLSTLGEQSNG
MWTVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYTEMLAIADQQYELHLSTLGEQSNG
Download Length: 357 bp
>T152824 NZ_CP066534:c3603532-3603430 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 101 a.a. Molecular weight: 11262.05 Da Isoelectric Point: 5.8961
>AT152824 WP_001140617.1 NZ_CP050387:3103-3405 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQKIADELLLENQLYLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQKIADELLLENQLYLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT152824 NZ_CP066534:3603423-3603568 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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