152797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2395043..2395545 Replicon chromosome
Accession NZ_CP050382
Organism Escherichia coli strain 52148

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag HB638_RS11315 Protein ID WP_000767831.1
Coordinates 2395291..2395545 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HB638_RS11310 Protein ID WP_001259255.1
Coordinates 2395043..2395294 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB638_RS11285 2390220..2391287 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HB638_RS11290 2391287..2392357 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
HB638_RS11295 2392354..2393658 - 1305 WP_001446927.1 histidinol dehydrogenase -
HB638_RS11300 2393664..2394563 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HB638_RS11305 2394709..2394759 - 51 WP_001364200.1 his operon leader peptide -
HB638_RS11310 2395043..2395294 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HB638_RS11315 2395291..2395545 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HB638_RS11320 2395628..2396452 + 825 WP_000754737.1 SDR family oxidoreductase -
HB638_RS11325 2396498..2397427 + 930 Protein_2203 LysR family transcriptional regulator -
HB638_RS11330 2397642..2397704 + 63 WP_010723108.1 membrane protein YoeI -
HB638_RS11335 2397694..2399052 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HB638_RS11340 2399231..2400289 + 1059 WP_000492321.1 transport protein YeeE -
HB638_RS11345 2400303..2400530 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T152797 WP_000767831.1 NZ_CP050382:2395291-2395545 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

>T152797 NZ_CP066526:c9648-9334 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT152797 WP_001259255.1 NZ_CP050382:2395043-2395294 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT152797 NZ_CP066526:c9914-9636 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References