152770

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1562222..1562819 Replicon chromosome
Accession NZ_CP050376
Organism Klebsiella pneumoniae strain 51015

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag HB813_RS07550 Protein ID WP_004142563.1
Coordinates 1562222..1562539 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HB813_RS07555 Protein ID WP_004142561.1
Coordinates 1562532..1562819 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB813_RS07535 1557922..1559349 - 1428 WP_009308097.1 MFS transporter -
HB813_RS07540 1559458..1560324 + 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
HB813_RS07545 1560994..1562037 + 1044 WP_020325241.1 DUF2157 domain-containing protein -
HB813_RS07550 1562222..1562539 + 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB813_RS07555 1562532..1562819 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HB813_RS07560 1563084..1563737 - 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HB813_RS07565 1563857..1564225 - 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
HB813_RS07570 1564225..1564806 - 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
HB813_RS07575 1564986..1566101 + 1116 WP_020325248.1 MBL fold metallo-hydrolase -
HB813_RS07580 1566132..1566473 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HB813_RS07585 1566491..1566739 - 249 WP_020325243.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T152770 WP_004142563.1 NZ_CP050376:1562222-1562539 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T152770 NZ_CP066517:c4764407-4763874 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT152770 WP_004142561.1 NZ_CP050376:1562532-1562819 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT152770 NZ_CP066517:c4764684-4764418 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References