Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 744728..745503 Replicon chromosome
Accession NZ_CP050348
Organism Klebsiella pneumoniae strain ZRKP02

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag HB787_RS03725 Protein ID WP_004150910.1
Coordinates 745018..745503 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HB787_RS03720 Protein ID WP_004150912.1
Coordinates 744728..745021 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB787_RS03700 739936..740538 - 603 WP_062954968.1 short chain dehydrogenase -
HB787_RS03705 740636..741547 + 912 WP_004188550.1 LysR family transcriptional regulator -
HB787_RS03710 741548..742696 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
HB787_RS03715 742707..744083 - 1377 WP_004217775.1 cystathionine beta-synthase -
HB787_RS03720 744728..745021 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HB787_RS03725 745018..745503 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
HB787_RS03730 746207..746800 + 594 WP_004188553.1 hypothetical protein -
HB787_RS03735 746897..747113 + 217 Protein_734 transposase -
HB787_RS03740 747719..748591 + 873 WP_004188557.1 ParA family protein -
HB787_RS03745 748591..748974 + 384 WP_004150906.1 hypothetical protein -
HB787_RS03750 748967..750334 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 746897..747049 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T152664 WP_004150910.1 NZ_CP050348:745018-745503 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T152664 NZ_CP066370:c308809-308510 [Shewanella putrefaciens]
ATGAAAAATAAACGCTATAAACTGAGTAAGTTAGCTCAAACTCACTTACTAAAGATTAAAGACTACACCATTCAACACTT
TTCTGAGTCGCAGTGGCACAAATACAAAGAAAGCCTAATATCCGGCTTGCAAATGTTAGCCGATAACCCCGGATTAGGCA
GAAGCTGCGAAGATATTTACCCCAACGGATTCTACTTTCCGATTGCTAAACACACCGCCTACTTCACAAAAGAAGACGAC
TTCATCCTCATCGTTGCCATGTTAGGCCAGCCACAACTACCACAAAATCATCTGAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT152664 WP_004150912.1 NZ_CP050348:744728-745021 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT152664 NZ_CP066370:c309060-308818 [Shewanella putrefaciens]
GTGCAAACATTAACAGCCAATGACGCCAAACGAAATTTCGGTGAGTTACTGCTAAACGCTCAACGTGAACCCATCAAGAT
CAGCAAAAACAGTAAAGATGCGGTTGTTGTGATGTCTATCCACGATTACGAACAGCTTGAGGCGATGAAAGCCGACTATC
TGAAGCACTGTTTCAACGCAGCCAAAGAAGACTTAGCGAAAGGTAATATTGTTGATGGTGAAGATTTTCTTAACGCCCTG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References