Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 330005..330591 Replicon chromosome
Accession NZ_CP050348
Organism Klebsiella pneumoniae strain ZRKP02

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HB787_RS01540 Protein ID WP_002920800.1
Coordinates 330223..330591 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag HB787_RS01535 Protein ID WP_002920802.1
Coordinates 330005..330226 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB787_RS01515 326162..327088 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HB787_RS01520 327085..328362 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
HB787_RS01525 328359..329126 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HB787_RS01530 329128..329841 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HB787_RS01535 330005..330226 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HB787_RS01540 330223..330591 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HB787_RS01545 330864..332180 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HB787_RS01550 332287..333174 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HB787_RS01555 333171..334016 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HB787_RS01560 334018..335088 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 327085..335825 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T152662 WP_002920800.1 NZ_CP050348:330223-330591 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T152662 NZ_CP066369:c3883815-3882514 [Shewanella putrefaciens]
ATGAGTACTGCCAAAACGCTCACGTTAGAGATGTACCTCGGTGATTTGATTATCGGGGAATTATCCTTTGATTCCACGAC
CGACACCTTTGCAGTGCATTACACCGAAAAGTGGCAGCAGAGCGGATTTCCACTATCCCCGACCATTCCCTTAAATGGCA
CAGGAACGAGCAATCAAATATCGATGTTCTTGGTTAACTTATTGCCAGAAAACAAAGGATTAGATTACCTAATTGAATCT
CTTGGTGTCTCCAAGGGGAATACCTTTGCCTTGATCCGCGCAATTGGCTTAGATACCGCAGGTGCCGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAAATGCGGCCAATTATGGCTGCAGAAGTTATTCAGCGGATTGAAGATCCCACTA
TGTGGCCGATGGAAATTTGGGATGGCAAACCTCGACTGTCGGTAGCGGGGGTTCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGTGCGCTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGTCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATTGTTCATTTTGGCCGTT
ACAAAGCCCTCTGCGTTGAACGCTTTGACAGACGTTATATGGCAAGTGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCCCTTGGTTTTAGTGTCAGTAAAAAATATGAACGTAACTTTGGTACGGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTGAGTTTTAACAGGCTCTTTAGTCTTGCAGCAAAATGCCGTAATCCAGTGGCCGCTAAACAGGATATGTTGC
AATGGGCACTATTCAACTTACTGAGTGGTAATGCCGATGCGCACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAAGAGCTTGCAATGGCAATTGA
TGACGAATTTGATCCAAATAGCATTTATGCCTATCAATTCGCCGCATTTATCGATGGCTTAGGTTTACCAAGAAGTCTAT
TAATCAGTAACTTAACTAGAATGACGCGAAGGATATCGCAGCTAATAGATGAGGTGATTTCAATACTTCCGCCACTCGAT
GAAGATGAAGCAGTATTCGTGGCTCATTACAAAGCGCTGTTACTGGCGAGATGTGAGCGTTACCTTAGTATGACCGCCGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT152662 WP_002920802.1 NZ_CP050348:330005-330226 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT152662 NZ_CP066369:c3884055-3883819 [Shewanella putrefaciens]
ATGGCATTACCGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGTAGGAAAAGTGCTGCTCTTACCCAAGACGT
GGCGGCTATGCTGTGTGGCGTGACCAAAAAAACCTTGATCCGTGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGATATCGTTTCGGCTCAAACAAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References