Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4755470..4756151 Replicon chromosome
Accession NZ_CP050335
Organism Pseudomonas aeruginosa strain DVT401

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag HB725_RS22125 Protein ID WP_003111825.1
Coordinates 4755786..4756151 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag HB725_RS22120 Protein ID WP_003159602.1
Coordinates 4755470..4755793 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB725_RS22085 4751255..4752958 + 1704 WP_024947443.1 50S ribosome-binding GTPase -
HB725_RS22090 4753023..4753328 - 306 Protein_4369 IS21 family transposase -
HB725_RS22095 4753681..4753908 + 228 WP_014603215.1 hypothetical protein -
HB725_RS22100 4753923..4754465 - 543 WP_019396018.1 tyrosine-type recombinase/integrase -
HB725_RS22105 4754573..4754848 - 276 WP_004353146.1 hypothetical protein -
HB725_RS22110 4754848..4755180 - 333 WP_021205399.1 hypothetical protein -
HB725_RS22115 4755235..4755354 + 120 Protein_4374 IS5/IS1182 family transposase -
HB725_RS22120 4755470..4755793 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
HB725_RS22125 4755786..4756151 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB725_RS22130 4756442..4756810 - 369 WP_162471085.1 hypothetical protein -
HB725_RS22135 4756823..4757095 + 273 WP_014603216.1 hypothetical protein -
HB725_RS22140 4757125..4757550 - 426 WP_003116492.1 VOC family protein -
HB725_RS22145 4757651..4758535 + 885 WP_016263831.1 LysR family transcriptional regulator -
HB725_RS22150 4758508..4759461 - 954 WP_003085661.1 LysR family transcriptional regulator -
HB725_RS22155 4759682..4760116 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T152612 WP_003111825.1 NZ_CP050335:c4756151-4755786 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T152612 NZ_CP066356:7445713-7446135 [Bradyrhizobium elkanii USDA 76]
GTGATCCTGCTTGATACCAATGTGGTCTCCGAGGCGATGAAGCCCGAACCGCATCCATCGGTCCGCCACTGGCTCGACGC
CCAAGCGGCCGAGACGGTGTTTCTTTCCAGCGTTACCGTCGCCGAACTTTTGTTCGGTATCGGCGCGCTGCCGCGCGGCA
GGCGCAAGGACAGGCTGGCAGTTGCGCTCGACGGCGTGCTGGACCTTTTCACGGCCCGCATCCTGCCCTTCGATACCGCC
GCGGCGCGGCGCTATGCCGAACTCGCCGTTAAGGCGCGCGCGGCCGGAAAAGGCTTCCCCACGCCCGATGGCTACATCGC
CGCGATCGCCGCCGCACACGGCTTCGCGGTGGCATCGCGCGACACGAGTGCGTTCAATGCTGCCGGTCTGACGATAATCG
ATCCCTGGACTGCAACCAGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT152612 WP_003159602.1 NZ_CP050335:c4755793-4755470 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT152612 NZ_CP066356:7445462-7445716 [Bradyrhizobium elkanii USDA 76]
ATGGCCGCTGTCACCATCCGCAACCTCTCTGAGGAGGCGCATCGCGCCCTGAAAGTCCGTGCGGCGCAGCACAATCGCAG
CGCGGAAGCGGAAATGCGCGCCATTCTGGAGGCCGCCGTGCGTCCCCAGGGCCGGCTGCGGCTAGGCACCGCCCTTTCGG
AGATGAGCCGCAAGATTGGCCTCACCAATGCCGATGTCGAGGCACTTGAACATGGGCGCGACGTGCGTCCCGCTGAGCCG
ATGCACCTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References