Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5905796..5906391 Replicon chromosome
Accession NZ_CP050332
Organism Pseudomonas aeruginosa strain DVT413

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag HB730_RS27985 Protein ID WP_003113526.1
Coordinates 5906113..5906391 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag HB730_RS27980 Protein ID WP_003111575.1
Coordinates 5905796..5906101 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB730_RS27945 5900937..5901785 + 849 WP_009878189.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
HB730_RS27955 5901952..5902893 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
HB730_RS27960 5903010..5903624 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
HB730_RS27965 5903666..5904250 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
HB730_RS27970 5904291..5905391 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
HB730_RS27980 5905796..5906101 - 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
HB730_RS27985 5906113..5906391 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB730_RS27990 5906720..5908948 + 2229 WP_034036795.1 TonB-dependent receptor -
HB730_RS27995 5909018..5909665 - 648 WP_003095021.1 carbonate dehydratase -
HB730_RS28000 5909727..5910965 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T152595 WP_003113526.1 NZ_CP050332:c5906391-5906113 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T152595 NZ_CP066339:c4803496-4803146 [Alicyclobacillus sp. SO9]
TTGAATGTCAAACGAGGGGACATTTTTTTTGCCGATTTGTCGCCAGTGGTCGGATCGGAGCAAGGAGGATTCCGGCCGGT
TTTGGTGATCCAGAATGATATTGGCAATCGATTTAGCCCCACCGTAATTGTGGCTGCTATTACGGCACAGATCCAAAAAG
CAAAACTACCGACTCATGTGGAAATCCCGGCCGACAAATATGGATTGGACCGGGATTCGGTCATCTTGTTGGAACAACTT
CGTACAATAGATAAGCAGAGACTTACTGACAAGATTACTCACTTAGATGAAACTATGATGAGACTGGTGAATGAGGGTTT
ACAAATCAGTCTTGGGATGGTTGATTTCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT152595 WP_003111575.1 NZ_CP050332:c5906101-5905796 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT152595 NZ_CP066339:c4803773-4803501 [Alicyclobacillus sp. SO9]
GTGTCTGCTAACAAGCGCATTGTAGTCTACGTTCCGCAAAATTTACTGGAGCAAGTTGATGGAGTAGCGTTGCGGGAAAA
CACCAATCGGAGCGAGGTTTTTCGAGAAGCCATGCAAATGTACTTGTCAGAACAACGGAAGCAGGATATTCGGGCTTTGA
TGCAGCAAGGTTACGTGGAGATGGCAAGACTGAACTTACGAATTGCCTCGGAGGCCTTTCCACTGGAGGAAGAAGCGGGA
GGTACAGTCGAACGTCTAGTGAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References