Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 2886545..2887320 | Replicon | chromosome |
| Accession | NZ_CP050332 | ||
| Organism | Pseudomonas aeruginosa strain DVT413 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | V6ADY6 |
| Locus tag | HB730_RS13825 | Protein ID | WP_009518525.1 |
| Coordinates | 2886862..2887320 (+) | Length | 153 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | V6AEP7 |
| Locus tag | HB730_RS13820 | Protein ID | WP_023098543.1 |
| Coordinates | 2886545..2886862 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HB730_RS13800 | 2881715..2883103 | - | 1389 | Protein_2727 | efflux RND transporter permease subunit | - |
| HB730_RS13805 | 2883240..2884151 | + | 912 | WP_023098540.1 | NAD(P)H-binding protein | - |
| HB730_RS13810 | 2884300..2884446 | + | 147 | WP_023098541.1 | MerR family DNA-binding transcriptional regulator | - |
| HB730_RS13815 | 2884428..2886245 | - | 1818 | WP_023098542.1 | TraI domain-containing protein | - |
| HB730_RS13820 | 2886545..2886862 | + | 318 | WP_023098543.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| HB730_RS13825 | 2886862..2887320 | + | 459 | WP_009518525.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| HB730_RS13830 | 2887347..2887724 | + | 378 | WP_009518524.1 | DUF3742 family protein | - |
| HB730_RS13835 | 2887740..2889257 | - | 1518 | WP_009518523.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
| HB730_RS13840 | 2889272..2889631 | - | 360 | WP_009518522.1 | hypothetical protein | - |
| HB730_RS13845 | 2889628..2891022 | - | 1395 | WP_009518521.1 | integrating conjugative element protein | - |
| HB730_RS13850 | 2891032..2891979 | - | 948 | WP_009518520.1 | TIGR03756 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2816098..2951414 | 135316 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 17660.02 Da Isoelectric Point: 10.1848
>T152589 WP_009518525.1 NZ_CP050332:2886862-2887320 [Pseudomonas aeruginosa]
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE
Download Length: 459 bp
>T152589 NZ_CP066312:c71735-71163 [Azotobacter chroococcum]
GTGAGCTCGAACTACACGGTCGTCTACGATGCCTGCGTGATGTATCCGGCACCGTTGCGCAGCCTGCTGATGTACCTGGC
GCTATCCGGTCAGTTCCGCGCCCGCTGGTCGGAAACCATCCATCAGGAATGGATGCGGAATCTGCTGGCCGATCGTCCCG
ACTTGTCGCCTGACACGGTCGGGCGTGTACGAGAGCTGATGGATCGTCATGTGCCGGGAGCCCTGGTGACGGGCTTCGAG
AGCCTGATCCCTGGCATTACCCTCCCGGATCCGGAGGACCGCCATGTGGTAGCGGCCGCGGTGCAGACGCGCGCCGAAGC
GATCGTGACCTTCAATCTCAAGGATTTTCCCGACCAGGATCTGTCTCCCTTCGGGGTGCGGGCCATCCATCCGGACGACT
TCATCACAGACCTGATGGAACTGCACATCGGCGCCGTGCTCGAGGCCGTTCGCCGTCACCGGGCATCGCTGAAGAACCCT
CCCTTTTCCTCTCGCGAGTACCTGGACTGCCTGTTGAAGCAACGCTTGCCGGAAACCGTTTCCCGGCTTCGCGCGTTCGA
GCTGCTCATCTGA
GTGAGCTCGAACTACACGGTCGTCTACGATGCCTGCGTGATGTATCCGGCACCGTTGCGCAGCCTGCTGATGTACCTGGC
GCTATCCGGTCAGTTCCGCGCCCGCTGGTCGGAAACCATCCATCAGGAATGGATGCGGAATCTGCTGGCCGATCGTCCCG
ACTTGTCGCCTGACACGGTCGGGCGTGTACGAGAGCTGATGGATCGTCATGTGCCGGGAGCCCTGGTGACGGGCTTCGAG
AGCCTGATCCCTGGCATTACCCTCCCGGATCCGGAGGACCGCCATGTGGTAGCGGCCGCGGTGCAGACGCGCGCCGAAGC
GATCGTGACCTTCAATCTCAAGGATTTTCCCGACCAGGATCTGTCTCCCTTCGGGGTGCGGGCCATCCATCCGGACGACT
TCATCACAGACCTGATGGAACTGCACATCGGCGCCGTGCTCGAGGCCGTTCGCCGTCACCGGGCATCGCTGAAGAACCCT
CCCTTTTCCTCTCGCGAGTACCTGGACTGCCTGTTGAAGCAACGCTTGCCGGAAACCGTTTCCCGGCTTCGCGCGTTCGA
GCTGCTCATCTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11170.72 Da Isoelectric Point: 4.7182
>AT152589 WP_023098543.1 NZ_CP050332:2886545-2886862 [Pseudomonas aeruginosa]
MPAIHEVATLTSKGQITLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNVRGLPED
LARAMLEHAGHGVNLDEEIDGKVEL
MPAIHEVATLTSKGQITLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNVRGLPED
LARAMLEHAGHGVNLDEEIDGKVEL
Download Length: 318 bp
>AT152589 NZ_CP066312:c72190-71732 [Azotobacter chroococcum]
ATGAACCGCCTGCAAGAAACACTGCCCAGCGCCGAAGAGGCCACTCTGGCCAAACTGTGCAGCCAGGAGCTGTCCGCCAT
TATCGAAACCCGCGCGGAGACGCAGACTCTGTCCATCAGCGATCCCAAGGGAGGGATTCGTTCCGTCAACATCCCGGTCA
GCGCCCTGCGTCTGCTGGTCGATGTGTTGACCGAGCTGGGTGAGGGCAACAGTGTCCGCCTGGTTCCCGTCCATGCGGAG
TTGACCACCCAGGAAGCGGCCGACCTGCTGAATGTGTCTCGCCCCACCTTGATCAAGCTGCTCGATGAGGGAGCCATCCC
CTACCATCGCGCCGGCAATCGCCGGAAGGTAAAATTTGCCGATCTCCGCCTCTACCAGGAGAGGCTTGAACAGGAGCGAC
TGGCGGCGCTGGCCGAGCTCTCTGCCTTGGACCAGGCACTGGGGCTGGGCTACGAGTGA
ATGAACCGCCTGCAAGAAACACTGCCCAGCGCCGAAGAGGCCACTCTGGCCAAACTGTGCAGCCAGGAGCTGTCCGCCAT
TATCGAAACCCGCGCGGAGACGCAGACTCTGTCCATCAGCGATCCCAAGGGAGGGATTCGTTCCGTCAACATCCCGGTCA
GCGCCCTGCGTCTGCTGGTCGATGTGTTGACCGAGCTGGGTGAGGGCAACAGTGTCCGCCTGGTTCCCGTCCATGCGGAG
TTGACCACCCAGGAAGCGGCCGACCTGCTGAATGTGTCTCGCCCCACCTTGATCAAGCTGCTCGATGAGGGAGCCATCCC
CTACCATCGCGCCGGCAATCGCCGGAAGGTAAAATTTGCCGATCTCCGCCTCTACCAGGAGAGGCTTGAACAGGAGCGAC
TGGCGGCGCTGGCCGAGCTCTCTGCCTTGGACCAGGCACTGGGGCTGGGCTACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|