Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4635136..4635817 Replicon chromosome
Accession NZ_CP050329
Organism Pseudomonas aeruginosa strain DVT417

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HB734_RS21500 Protein ID WP_033940085.1
Coordinates 4635452..4635817 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HB734_RS21495 Protein ID WP_033940084.1
Coordinates 4635136..4635459 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB734_RS21470 4630959..4631792 + 834 WP_003109433.1 metal-dependent hydrolase -
HB734_RS21475 4631927..4632868 - 942 WP_077144382.1 alpha/beta hydrolase -
HB734_RS21480 4632977..4633660 - 684 WP_003085795.1 TetR/AcrR family transcriptional regulator -
HB734_RS21485 4633748..4634626 + 879 WP_003163191.1 hypothetical protein -
HB734_RS21495 4635136..4635459 - 324 WP_033940084.1 XRE family transcriptional regulator Antitoxin
HB734_RS21500 4635452..4635817 - 366 WP_033940085.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB734_RS21505 4635856..4636854 - 999 WP_033940086.1 tyrosine-type recombinase/integrase -
HB734_RS21510 4636854..4638146 - 1293 WP_134299279.1 hypothetical protein -
HB734_RS21515 4638784..4639173 - 390 WP_033940089.1 hypothetical protein -
HB734_RS21520 4639166..4639380 - 215 Protein_4255 hypothetical protein -
HB734_RS21525 4639377..4639544 - 168 WP_116851226.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13908.29 Da        Isoelectric Point: 4.6863

>T152571 WP_033940085.1 NZ_CP050329:c4635817-4635452 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGLSLGHPYSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYEVNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T152571 NZ_CP066308:471551-471901 [Brevibacillus sp. FJAT-54423]
GTGATTGTCAAACGTGGCGATGTATTTTTCGCGGACCTATCACCGGTTGTCGGCTCTGAACAGGGAGGGGTGCGACCCGT
ATTAGTCATCCAAAACGATATTGGCAATCGATTTAGTCCGACGGTCATCGTCGCAGCGATCACCGCGCAGATTCAGAAGG
CTAAACTGCCGACGCACGTGGAGATTGACGCAAAAATGTATGGATTCGACCGCGACTCCGTCATCTTGCTAGAACAAATC
CGAACCATTGATAAGCAGAGGCTGACCGATAAAATCACGCATCTGGACGATGAGATGATGGAGCGTGTCAATGAATCTCT
GCAAATCAGCCTGGGCATTATCGACTTTTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT152571 WP_033940084.1 NZ_CP050329:c4635459-4635136 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFGDIEEAGA

Download         Length: 324 bp

>AT152571 NZ_CP066308:471248-471547 [Brevibacillus sp. FJAT-54423]
ATGGTTGGAGGTGGATTCGTCTTGTCAAAGTCAAATACGAAACGTATTATGATTAGCCTGCCACATCACCTTCTTCAGGA
AGTGGACGGCGTCATTCAAAAAGAAAAATCCAATCGGAGTGAATTTATTCGCCAGGCAATGCACCTGTATCTGAAGGAGC
GCAAAAAACGCGCCATCCGGGAAACGATGCAAAAAGGGTACATGGAAATGGCTAAGATCAACTTGAATATGGCATCGGAG
GCATTTGGCGCTGAGGAAGAGGCTGACCATACTCTTGTCCGCTTAGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References