Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 724719..725314 Replicon chromosome
Accession NZ_CP050327
Organism Pseudomonas aeruginosa strain DVT421

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HB737_RS03395 Protein ID WP_071538299.1
Coordinates 724719..724997 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HB737_RS03400 Protein ID WP_003123432.1
Coordinates 725009..725314 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB737_RS03380 720145..721383 + 1239 WP_003113524.1 dipeptidase -
HB737_RS03385 721445..722092 + 648 WP_003095021.1 carbonate dehydratase -
HB737_RS03390 722162..724390 - 2229 WP_003113525.1 TonB-dependent receptor -
HB737_RS03395 724719..724997 + 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB737_RS03400 725009..725314 + 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
HB737_RS03410 725721..726821 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
HB737_RS03415 726862..727446 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
HB737_RS03420 727488..728102 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
HB737_RS03425 728219..729160 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
HB737_RS03435 729327..730175 - 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T152556 WP_071538299.1 NZ_CP050327:724719-724997 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T152556 NZ_CP066272:12745-13017 [Pseudomonas tremae]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAGATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCTTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT152556 WP_003123432.1 NZ_CP050327:725009-725314 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT152556 NZ_CP066272:12570-12755 [Pseudomonas tremae]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCA
GCGTATCGAGCACAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATCG
AAGCAAAGCGCCGCCGTGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References