Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2560607..2561256 Replicon chromosome
Accession NZ_CP050322
Organism Pseudomonas aeruginosa strain DVT729

Toxin (Protein)


Gene name higB Uniprot ID A0A8I0SCY9
Locus tag HB747_RS11995 Protein ID WP_003116649.1
Coordinates 2560912..2561256 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8I0SEX5
Locus tag HB747_RS11990 Protein ID WP_003116648.1
Coordinates 2560607..2560915 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB747_RS11970 2556105..2556593 + 489 WP_058173740.1 phosphate-starvation-inducible PsiE family protein -
HB747_RS11975 2556580..2557542 + 963 WP_003116644.1 M48 family metalloprotease -
HB747_RS11980 2557562..2558713 + 1152 WP_003116645.1 trypsin-like peptidase domain-containing protein -
HB747_RS11985 2559351..2560220 + 870 WP_003116646.1 LysR family transcriptional regulator -
HB747_RS11990 2560607..2560915 - 309 WP_003116648.1 transcriptional regulator Antitoxin
HB747_RS11995 2560912..2561256 - 345 WP_003116649.1 hypothetical protein Toxin
HB747_RS12000 2561414..2562340 - 927 WP_003116650.1 LysR family transcriptional regulator -
HB747_RS12005 2562354..2563553 - 1200 WP_003116651.1 MFS transporter -
HB747_RS12010 2563640..2565493 - 1854 WP_003116652.1 asparagine synthase (glutamine-hydrolyzing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2526991..2626650 99659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-92)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13324.20 Da        Isoelectric Point: 10.1223

>T152528 WP_003116649.1 NZ_CP050322:c2561256-2560912 [Pseudomonas aeruginosa]
MKALFVELSPFERNRKAHLDDDEYSLFQQMLLTNPEAGAVIANSGGLRKVRFGSVRRSKGKRGGVRVIYYYWHSGLQFWL
FTLYDKDELDDLSSDQRRQLKALLEREVKARQTP

Download         Length: 345 bp

>T152528 NZ_CP066253:c5028-4762 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11604.36 Da        Isoelectric Point: 10.0927

>AT152528 WP_003116648.1 NZ_CP050322:c2560915-2560607 [Pseudomonas aeruginosa]
MTKRDIFSELIEGFDDLASAREGKRTLRTHKVEYKPIEPATGAEIVALREKLQMSQGVFAQAIHAKPATLKNWEQNRSKP
NDQATVLIRILNKHPDLIRELA

Download         Length: 309 bp

>AT152528 NZ_CP066253:c5236-5012 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References