Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2923295..2923877 Replicon chromosome
Accession NZ_CP050301
Organism Phyllobacterium sp. 628

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HB779_RS16040 Protein ID WP_188343290.1
Coordinates 2923599..2923877 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HB779_RS16035 Protein ID WP_188343289.1
Coordinates 2923295..2923585 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB779_RS16015 2918372..2919118 - 747 WP_188343286.1 alanyl-tRNA editing protein -
HB779_RS16020 2919118..2920152 - 1035 WP_188343287.1 cysteine synthase A -
HB779_RS16025 2920323..2921657 - 1335 WP_188345963.1 DEAD/DEAH box helicase -
HB779_RS16030 2921992..2923191 - 1200 WP_188343288.1 HPP family protein -
HB779_RS16035 2923295..2923585 - 291 WP_188343289.1 HigA family addiction module antidote protein Antitoxin
HB779_RS16040 2923599..2923877 - 279 WP_188343290.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB779_RS16045 2923947..2924810 - 864 WP_188343291.1 DMT family transporter -
HB779_RS16050 2924961..2926385 + 1425 WP_188343292.1 PLP-dependent aminotransferase family protein -
HB779_RS16055 2926353..2926889 - 537 WP_188343293.1 DUF1697 domain-containing protein -
HB779_RS16060 2926886..2927440 - 555 WP_188343294.1 DUF1697 domain-containing protein -
HB779_RS16065 2927558..2928817 - 1260 WP_188343295.1 threonine ammonia-lyase IlvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10812.43 Da        Isoelectric Point: 10.2346

>T152490 WP_188343290.1 NZ_CP050301:c2923877-2923599 [Phyllobacterium sp. 628]
MIMRFRHKGLESFYRTGSIRGIQPAHAPKLSRILYALENATRSEELNLPGYRLHPLKGALKGHWSIWVNGNWRVTFRFDG
KDVELVDYLDYH

Download         Length: 279 bp

>T152490 NZ_CP066218:1580153-1580416 [Mycolicibacterium sp. LJ126]
TTGAGCTATCGAGTTGAGCTGACGAGGGCCGCGAAGAGGGCGTTGACCGAATCTCTGCCCGACACCGTTGCCGTCGCGTG
CTGGGAGTTCATCCGAGGTCCGCTGGCGGAGAACCCCTACCGCGTCGGCAAACCGCTCCGCGGTGAGTTAGAGGGTCGAT
TTTCGGCTCGGCGCGGCGAATTCCGCGTCATCTACCAGGTTTTCGACGACCGAGTTGTCGTCAGAGTCATCCACATTGGC
CACCGCCGTGACATCTATCGGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10502.20 Da        Isoelectric Point: 8.7038

>AT152490 WP_188343289.1 NZ_CP050301:c2923585-2923295 [Phyllobacterium sp. 628]
MMKTPPHPGELLREDVFEPLGMNVTEAASRLAISRVTLSRILNGKAGISPDLAIRLERAGVSTARFWLTLQTSYELAKAL
QHEQPPVKAIQLPDAA

Download         Length: 291 bp

>AT152490 NZ_CP066218:1580540-1580746 [Mycolicibacterium sp. LJ126]
GTGCGGACGACAGTCACGATCGACGATGAGCTGCTGGCCAAAGCCGCCGAACTGACGGGCGTCAAGGAAGACGTCGCTCT
ACTCAGGCGAGGTTTGCAGACGTTGATCCGCGTCGAGAGTGCTCGTCGTCTCGCCGCGCTCGGCGGAACAGATCCACAGG
CCCATGCGGCTCCCCGTCGACGTGAACCGACTGAATCGACCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References