Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 275589..276202 Replicon chromosome
Accession NZ_CP050296
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HB778_RS01330 Protein ID WP_183460844.1
Coordinates 275589..275885 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HB778_RS01335 Protein ID WP_019859111.1
Coordinates 275894..276202 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS01320 273499..274797 + 1299 WP_183460840.1 DUF3419 family protein -
HB778_RS01325 274794..275459 + 666 WP_183460842.1 class I SAM-dependent methyltransferase -
HB778_RS01330 275589..275885 + 297 WP_183460844.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB778_RS01335 275894..276202 + 309 WP_019859111.1 HigA family addiction module antidote protein Antitoxin
HB778_RS01340 276216..277595 - 1380 WP_183460845.1 serine hydrolase -
HB778_RS01345 277875..278675 + 801 WP_183460847.1 glycoside hydrolase family 25 protein -
HB778_RS01350 278915..280093 + 1179 WP_183460849.1 lytic murein transglycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11564.99 Da        Isoelectric Point: 6.8805

>T152471 WP_183460844.1 NZ_CP050296:275589-275885 [Mesorhizobium huakuii]
MIVGFRDGWLRAFFVDDSRSRNIPSDLESRLFRKLQMVDDAVTDLDLRVPPSNHFEKLRGNLEGFHSIRVNKQWRLVFHW
DGGRGEASDIYLDDHSYK

Download         Length: 297 bp

>T152471 NZ_CP066185:1396741-1397091 [Bacillus cytotoxicus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCAGCGATTACTGCACAGATTCAGAAAG
CAAAATTGCCCACGCATGTGGAGATTGATGCGAAGAAGTACGGATTTGAGAGGGATTCTGTGATCTTGCTCGAGCAGATT
CGAACAATTGATAAGCAACGCTTAACGGACAAAATCACACATTTAGATGAAGTGATGATGATTCGTGTAGATGAGGCTTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11332.09 Da        Isoelectric Point: 9.4051

>AT152471 WP_019859111.1 NZ_CP050296:275894-276202 [Mesorhizobium huakuii]
MLMTARKPATVGEILTEEFMQPLGLTQAALAEAMGVQRKHVNELCNDRRNVTAATALILARVFGNSPDFWLNVQRRSDLW
AVMNSPDERARVDRAKPLPTAA

Download         Length: 309 bp

>AT152471 NZ_CP066185:1396449-1396736 [Bacillus cytotoxicus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAGTGGTGACGGAATTGGACGGGATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAAAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References