Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 606332..606945 Replicon chromosome
Accession NZ_CP050292
Organism Tardiphaga robiniae strain 581

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HB776_RS02760 Protein ID WP_175365601.1
Coordinates 606332..606628 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HB776_RS02765 Protein ID WP_184514874.1
Coordinates 606637..606945 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB776_RS02740 601524..601724 + 201 WP_068734021.1 DUF2065 domain-containing protein -
HB776_RS02745 601924..603462 + 1539 WP_089268265.1 Do family serine endopeptidase -
HB776_RS02750 604472..605362 - 891 WP_184514871.1 phosphoserine phosphatase SerB -
HB776_RS02755 605366..606292 + 927 WP_184514873.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
HB776_RS02760 606332..606628 + 297 WP_175365601.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB776_RS02765 606637..606945 + 309 WP_184514874.1 HigA family addiction module antidote protein Antitoxin
HB776_RS02770 607427..609205 + 1779 WP_149532910.1 acetolactate synthase 3 large subunit -
HB776_RS02775 609369..609911 + 543 WP_068738461.1 acetolactate synthase small subunit -
HB776_RS02780 609930..610802 + 873 WP_184514876.1 EamA family transporter -
HB776_RS02785 610807..611409 + 603 WP_068738457.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11646.07 Da        Isoelectric Point: 6.8803

>T152469 WP_175365601.1 NZ_CP050292:606332-606628 [Tardiphaga robiniae]
MIVGFRDDWLRAFFVDDVHSRNIPADLESRLFRKLQMIDDATTDQDLRVPPSNHFEKLRGKLGGLHSIRVNNQWRLIFRW
DSSRGEASDLYLDDHSYR

Download         Length: 297 bp

>T152469 NZ_CP066184:c670769-670419 [Bacillus cytotoxicus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCAGCGATTACTGCACAGATTCAGAAAG
CAAAATTGCCCACGCATGTGGAGATTGATGCGAAGAAGTACGGATTTGAGAGGGATTCTGTGATCTTGCTCGAGCAGATT
CGAACAATTGATAAGCAACGCTTAACGGACAAAATCACACATTTAGATGAAGTGATGATGATTCGTGTAGATGAGGCTTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11445.34 Da        Isoelectric Point: 10.8919

>AT152469 WP_184514874.1 NZ_CP050292:606637-606945 [Tardiphaga robiniae]
MLMTKRKPATVGEILVEEFMQPRGLTQGTLAKAMGVQRKHVNELCNDRRNVTAATALILARVFGNSPDFWLNVQRRGDLW
EAMNSPQELARIERATPLVKAA

Download         Length: 309 bp

>AT152469 NZ_CP066184:c671061-670774 [Bacillus cytotoxicus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAGTGGTGACGGAATTGGACGGGATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAAAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References