Detailed information of TA system TA152446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1560165..1560765
• Replicon: chromosome
• Accession: NZ_CP050266
• Organism: Salinivibrio costicola strain M318

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HBA18_RS07385
• Protein ID: WP_167314445.1
• Coordinates: 1560165..1560488 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2A4GFS1
• Locus tag: HBA18_RS07390
• Protein ID: WP_069587053.1
• Coordinates: 1560481..1560765 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA18_RS16720	1558661..1558942	-	282	Protein_1412	hypothetical protein	-
HBA18_RS07380	1558939..1559910	-	972	WP_167314444.1	type I-F CRISPR-associated endonuclease Cas1	-
HBA18_RS07385	1560165..1560488	+	324	WP_167314445.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HBA18_RS07390	1560481..1560765	+	285	WP_069587053.1	helix-turn-helix domain-containing protein	Antitoxin
HBA18_RS07395	1562085..1562369	+	285	WP_167314446.1	TIGR03643 family protein	-
HBA18_RS07400	1562691..1563854	-	1164	WP_167314447.1	hypothetical protein	-
HBA18_RS07405	1563975..1565141	-	1167	WP_167314448.1	DnaJ domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-101)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-87)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12143.28 Da
• Isoelectric Point: 10.2189

>T152446 WP_167314445.1 NZ_CP050266:1560165-1560488 [Salinivibrio costicola]
MHWNIVFYRGVEESILNMPPKIQARMLKLLELIEKHGANLGPPHTESIGNGLFEIRAKAKEGIGRSLFCYLDGPNIYVLH
AFVKKSQKTPKKDLALATGRMREVKNE

Nucleotide

• Length: 324 bp

>T152446 NZ_CP066167:c736424-736170 [Spongiibacter sp. CSC3.9]
GTGAAGTTAATTTTTGCAGAGAAGGCATGGGAGGATTACCTGTACTGGCAAAAAACGGACAAACAGACACTGAAACGTAT
TAATACCCTTATCAAGGAAATCAAACGAGAACCATTCGAAGGCATTGGAAAGCCAGAGCCGCTCAAACATGCCCTTTCGG
GGTATTGGTCTCGAAGGATTAACGATGAGCACCGAATGGTTTATAAAATTCATCAAGATTCCCTGCTTATTGCCCAACTT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10559.17 Da
• Isoelectric Point: 9.8481

>AT152446 WP_069587053.1 NZ_CP050266:1560481-1560765 [Salinivibrio costicola]
MNSLQALKARALQNPDVKQAYDELTPEFELIDMLLSMRKQAGLTQQQVAERMGTKEGNISRLEKGKGNPTVKTLFNYAKA
CNCKLNFGYKHAPN

Nucleotide

• Length: 285 bp

>AT152446 NZ_CP066167:c736672-736421 [Spongiibacter sp. CSC3.9]
ATGGACAGTATAAGCTATACCGCCGCCAGGAGCAACTTGGCGAAAACTATGGAGCAGGTCTGTAACGACCATGCGCCCAT
TGCTATTACCCGCAAGGGCGAAGGTGCCGTTGTGATGATTTCTATGGACGACTACCAAGCCTTGGAAGAAACGGCATATC
TGCTTCGGAGCCCCAAAAATACCCGACGCCTGATCGAGTCTATTGCCGAGCTTGAGGACGGCAAAGGCCAAGAAAAGGAA
TTGATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2A4GFS1