Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1663452..1663964 Replicon chromosome
Accession NZ_CP050175
Organism Streptococcus pneumoniae strain PZ900701590

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag HA248_RS08510 Protein ID WP_000924721.1
Coordinates 1663452..1663706 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag HA248_RS08515 Protein ID WP_000388572.1
Coordinates 1663710..1663964 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA248_RS08495 1660553..1660867 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
HA248_RS08500 1660892..1661518 - 627 WP_000775037.1 guanylate kinase -
HA248_RS08505 1661648..1663261 - 1614 WP_000404940.1 ribonuclease Y -
HA248_RS08510 1663452..1663706 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
HA248_RS08515 1663710..1663964 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HA248_RS08520 1664202..1665299 - 1098 WP_166735724.1 nucleotidyltransferase -
HA248_RS08525 1665309..1666055 - 747 WP_166735725.1 class I SAM-dependent methyltransferase -
HA248_RS08530 1666158..1666511 - 354 WP_001003001.1 ribosome silencing factor -
HA248_RS08535 1666524..1667024 - 501 WP_000844707.1 cysteine hydrolase -
HA248_RS08540 1667025..1667618 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
HA248_RS08545 1667618..1668247 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
HA248_RS08550 1668299..1668610 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T152379 WP_000924721.1 NZ_CP050175:c1663706-1663452 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T152379 NZ_CP066139:1835-2101 [Morganella morganii]
TTGGCTTGGACGATTAACTACTCTGATAAAGCATTAAAATCACTTCGTAAGATGGATAAACAGAATGCACGAAGGATTGT
CGATTTTATGGATCTTCGCATTGCTGTATTAGATGATCCTCGACAGTCAGGGAAGTCACTGAAAGGAGAGCTAGGTGAAT
TTTGGAGGTATAGAGTAGGTGATTACCGTATACTCTGTGAAATAAGAGATGCTGAACTCATTATACTGGCAGCTACAATA
GGGCATCGTAGTGATGTGTATGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT152379 WP_000388572.1 NZ_CP050175:c1663964-1663710 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT152379 NZ_CP066139:1627-1851 [Morganella morganii]
ATGTTAGCTATTCGCTTATCTGATGATATTGAGTCACGGTTAAACTCTCTCGCAAAACAAACAGGTAGAACAAAAACGTT
CTATGCCAGAGAAGCTATTCTCACCCACCTTGAGGATCTGGAGGACTACTACCTTTCAGCCGAAACTATCGCCAAAATAC
GGAGTGGTGATGAACAGGTTCACTCATCTACTGATGTAAGGAAGTCTCTTGGCTTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References