Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2469725..2470363 Replicon chromosome
Accession NZ_CP050173
Organism Escherichia coli strain STB20-1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag FIP50_RS11985 Protein ID WP_000813794.1
Coordinates 2470187..2470363 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FIP50_RS11980 Protein ID WP_001270286.1
Coordinates 2469725..2470141 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIP50_RS11960 2464877..2465818 - 942 WP_001251304.1 ABC transporter permease -
FIP50_RS11965 2465819..2466832 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
FIP50_RS11970 2466850..2467995 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
FIP50_RS11975 2468240..2469646 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
FIP50_RS11980 2469725..2470141 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FIP50_RS11985 2470187..2470363 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FIP50_RS11990 2470585..2470815 + 231 WP_000494244.1 YncJ family protein -
FIP50_RS11995 2470907..2472868 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FIP50_RS12000 2472941..2473477 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
FIP50_RS12005 2473530..2474744 + 1215 WP_074400818.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2474784..2475932 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T152371 WP_000813794.1 NZ_CP050173:c2470363-2470187 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T152371 NZ_CP066133:3325667-3325870 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT152371 WP_001270286.1 NZ_CP050173:c2470141-2469725 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT152371 NZ_CP066133:3325245-3325604 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References