Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2836437..2837083 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name higB Uniprot ID A0A8H9YI82
Locus tag HAP32_RS13150 Protein ID WP_071681705.1
Coordinates 2836437..2836787 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HAP32_RS13155 Protein ID WP_141130932.1
Coordinates 2836784..2837083 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP32_RS13130 2832296..2833315 + 1020 WP_166733826.1 dipeptide ABC transporter permease DppB -
HAP32_RS13135 2833327..2834229 + 903 WP_166733827.1 dipeptide ABC transporter permease DppC -
HAP32_RS13140 2834244..2835224 + 981 WP_021807726.1 dipeptide ABC transporter ATP-binding protein -
HAP32_RS13145 2835221..2836210 + 990 WP_021807727.1 ABC transporter ATP-binding protein -
HAP32_RS13150 2836437..2836787 + 351 WP_071681705.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAP32_RS13155 2836784..2837083 + 300 WP_141130932.1 helix-turn-helix transcriptional regulator Antitoxin
HAP32_RS13160 2837245..2838900 - 1656 WP_166733828.1 cellulose biosynthesis protein BcsG -
HAP32_RS13165 2838903..2839100 - 198 WP_021807731.1 cellulose biosynthesis protein BcsF -
HAP32_RS13170 2839097..2840659 - 1563 WP_166733829.1 cellulose biosynthesis protein BcsE -
HAP32_RS13175 2840854..2841048 + 195 WP_166733830.1 hypothetical protein -
HAP32_RS13180 2841052..2841789 + 738 WP_166733831.1 cellulose synthase operon protein YhjQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13589.51 Da        Isoelectric Point: 5.2166

>T152351 WP_071681705.1 NZ_CP050171:2836437-2836787 [Serratia fonticola]
MWTVIFTSTFDSWLQEQEEGMQEKVLADLMNLETYGPQLPRPYADTVKGSRYKNMKELRVQYSGRPIRAFFVFDPKRQAI
VLCAGDKSNDKRFYDTMIRIADDEFTAYLAIQEVSK

Download         Length: 351 bp

>T152351 NZ_CP066126:4803419-4803835 [Chromobacterium rhizoryzae]
GTGTATCTGGTGGACACCAATATCGTCAGCGAAGCTCGCAAAGGCGGCAAAGCCAATGCAGGCGTGCTCGCCTTCTGGCG
ATCGGCGGACACGGACAGCCTCTATCTGTCCGCCATCAGCGTGGGGGAAATTCGCCGCGGCATCGAGAATCTCAAGCACC
GCGGCGACCTCAAGCAGGCCGGCCTGCTGGAACAATGGCTGGACACCATCACCCAGGAATTTTCCCAACGCATTCTGAAC
TTCGATGCCGATTGCGCCCAGGTATGGGGCAAGTTGATGTCCCCTCATCCCCAGAACGCCGTCGACAAGCAAATCGCCGC
CATCGCGCTGATCCACGACCTGACGATCGTGACCCGCAATAGCGGCGATTTTGCCGGCACCGGCGTCAAACTATTGAACC
CGTTCGCTCCGATCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10836.61 Da        Isoelectric Point: 7.0149

>AT152351 WP_141130932.1 NZ_CP050171:2836784-2837083 [Serratia fonticola]
MKTLRDAVAARSLESQARIKAMADEMMLETGLQLMRDELQLSQKSLAEAMGVSQSAVAQIEQRGNDVKLATLKRYIEAMG
GKLSLTVEMPEGGGRVFHI

Download         Length: 300 bp

>AT152351 NZ_CP066126:4803203-4803415 [Chromobacterium rhizoryzae]
ATGGCCAATCTGATCGTGCGCAATATCGACGATGAAGTCGCCGCGGAGCTCAAACGTCGCGCGGCGGCCCACGGCGTCAG
CGCCGAAGCCGAGCATCGCCGCATTCTGCGCAGCGCCTTGCTCGCTCAACCCAAACGCCGCAGCTTTGCCGAAGTCCTGG
CCAATATGCCCGACGTGGGCGAAGACGCCGACTTCGAACGCAGCCGGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References