Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 625612..626271 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name higB Uniprot ID A0A0F7HHG5
Locus tag HAP32_RS03035 Protein ID WP_024486065.1
Coordinates 625918..626271 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U2NFA4
Locus tag HAP32_RS03030 Protein ID WP_021180280.1
Coordinates 625612..625914 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP32_RS03010 620935..622107 + 1173 WP_208295973.1 flavin-dependent monooxygenase -
HAP32_RS03015 622128..623072 + 945 WP_071680978.1 flavin reductase family protein -
HAP32_RS03020 623145..624347 - 1203 WP_166732928.1 Bcr/CflA family multidrug efflux MFS transporter -
HAP32_RS03025 624608..625468 - 861 WP_166732929.1 aldo/keto reductase family oxidoreductase -
HAP32_RS03030 625612..625914 - 303 WP_021180280.1 XRE family transcriptional regulator Antitoxin
HAP32_RS03035 625918..626271 - 354 WP_024486065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAP32_RS03040 626529..627716 - 1188 WP_166732930.1 sugar transporter -
HAP32_RS03045 627922..628653 - 732 WP_166732931.1 molecular chaperone -
HAP32_RS03050 628653..630002 - 1350 WP_166732932.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13575.50 Da        Isoelectric Point: 9.5694

>T152344 WP_024486065.1 NZ_CP050171:c626271-625918 [Serratia fonticola]
VWEIKTTDTFDEWFSRLEDTDRASVLASLIVLREKGPQLPRPYADTVKGSRYSNMKELRVQSRGIPIRAFFAFDPRRRGI
LLCAGSKAGNEKRFYEVMIPIADREFTQFLNTAENKE

Download         Length: 354 bp

>T152344 NZ_CP066124:3090512-3090802 [Acinetobacter pittii]
ATGACTATTAAGTTGAAAAAATGGGATATACAGGATCATCTTAAAACAGAAGAAGAGCGCCAAGCTTATTTAGAAGCGGC
ACTAGAAGAAGCTAGTGATGATCCTTTATATATTGCTCATGTCTTAGGCGACATAGCTAAATCATATGGAATGACTAAGC
TTGCGCAAGAAACAGGGTTAACTCGTGAAGGTTTATACAAATCCTTTGGCAAACAAGGCAATCCCAGCTTTGTAACTGTT
AGTAAAGTAGCAAGTGCTATGGGCTTAAAGTTAACTTTTGAACATGCATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11022.78 Da        Isoelectric Point: 6.4749

>AT152344 WP_021180280.1 NZ_CP050171:c625914-625612 [Serratia fonticola]
MGRTLEQILAEEKPEVVASAERIAADTLLNIHLAELRERVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSSLKRYIEAA
GGKLRLDIELPDGSHYGFVI

Download         Length: 303 bp

>AT152344 NZ_CP066124:3090213-3090515 [Acinetobacter pittii]
ATGTATGAAATCAAGACGACCGAAACCTTTGATGAATGGTTTGATTCATTAAGAGACACACAAGGTAAAGCTCGCATAAA
TGCTCGTTTGCGTCGTGTTGAGCTGGGTAATTTCGGTGACGCAGAACCTGTTGGTGAAAACGTGTCTGAATTAAGATTTT
TCTTTGGCCCCGGCTATAGAATTTATTTCATACAAAATGGTGATGAAATCATTGTCTTACTAGCTGGTGGAGATAAATCT
TCACAGCAAAAAGATATTGATAAGGCTATTGAATTAGCAAAAGAAATTCGAGGTGAGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7HHG5

Antitoxin

Source ID Structure
AlphaFold DB U2NFA4

References