Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 625612..626271 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name higB Uniprot ID A0A0F7HHG5
Locus tag HAP32_RS03035 Protein ID WP_024486065.1
Coordinates 625918..626271 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U2NFA4
Locus tag HAP32_RS03030 Protein ID WP_021180280.1
Coordinates 625612..625914 (-) Length 101 a.a.

Genomic Context

HAP32_RS03010HAP32_RS03015HAP32_RS03020HAP32_RS03025HAP32_RS03030HAP32_RS03035HAP32_RS03040HAP32_RS03045HAP32_RS03050
Location: 620935..622107 (1173 bp)
Type: Others
Protein ID: WP_208295973.1
Location: 622128..623072 (945 bp)
Type: Others
Protein ID: WP_071680978.1
Location: 623145..624347 (1203 bp)
Type: Others
Protein ID: WP_166732928.1
Location: 624608..625468 (861 bp)
Type: Others
Protein ID: WP_166732929.1
Location: 625612..625914 (303 bp)
Type: Antitoxin
Protein ID: WP_021180280.1
Location: 625918..626271 (354 bp)
Type: Toxin
Protein ID: WP_024486065.1
Location: 626529..627716 (1188 bp)
Type: Others
Protein ID: WP_166732930.1
Location: 627922..628653 (732 bp)
Type: Others
Protein ID: WP_166732931.1
Location: 628653..630002 (1350 bp)
Type: Others
Protein ID: WP_166732932.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HAP32_RS03010620935..622107+1173WP_208295973.1flavin-dependent monooxygenase-
HAP32_RS03015622128..623072+945WP_071680978.1flavin reductase family protein-
HAP32_RS03020623145..624347-1203WP_166732928.1Bcr/CflA family multidrug efflux MFS transporter-
HAP32_RS03025624608..625468-861WP_166732929.1aldo/keto reductase family oxidoreductase-
HAP32_RS03030625612..625914-303WP_021180280.1XRE family transcriptional regulatorAntitoxin
HAP32_RS03035625918..626271-354WP_024486065.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HAP32_RS03040626529..627716-1188WP_166732930.1sugar transporter-
HAP32_RS03045627922..628653-732WP_166732931.1molecular chaperone-
HAP32_RS03050628653..630002-1350WP_166732932.1fimbrial protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13575.50 Da        Isoelectric Point: 9.5694

>T152344 WP_024486065.1 NZ_CP050171:c626271-625918 [Serratia fonticola]
VWEIKTTDTFDEWFSRLEDTDRASVLASLIVLREKGPQLPRPYADTVKGSRYSNMKELRVQSRGIPIRAFFAFDPRRRGI
LLCAGSKAGNEKRFYEVMIPIADREFTQFLNTAENKE

Download         Length: 354 bp

>T152344 NZ_CP066124:3090512-3090802 [Acinetobacter pittii]
ATGACTATTAAGTTGAAAAAATGGGATATACAGGATCATCTTAAAACAGAAGAAGAGCGCCAAGCTTATTTAGAAGCGGC
ACTAGAAGAAGCTAGTGATGATCCTTTATATATTGCTCATGTCTTAGGCGACATAGCTAAATCATATGGAATGACTAAGC
TTGCGCAAGAAACAGGGTTAACTCGTGAAGGTTTATACAAATCCTTTGGCAAACAAGGCAATCCCAGCTTTGTAACTGTT
AGTAAAGTAGCAAGTGCTATGGGCTTAAAGTTAACTTTTGAACATGCATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11022.78 Da        Isoelectric Point: 6.4749

>AT152344 WP_021180280.1 NZ_CP050171:c625914-625612 [Serratia fonticola]
MGRTLEQILAEEKPEVVASAERIAADTLLNIHLAELRERVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSSLKRYIEAA
GGKLRLDIELPDGSHYGFVI

Download         Length: 303 bp

>AT152344 NZ_CP066124:3090213-3090515 [Acinetobacter pittii]
ATGTATGAAATCAAGACGACCGAAACCTTTGATGAATGGTTTGATTCATTAAGAGACACACAAGGTAAAGCTCGCATAAA
TGCTCGTTTGCGTCGTGTTGAGCTGGGTAATTTCGGTGACGCAGAACCTGTTGGTGAAAACGTGTCTGAATTAAGATTTT
TCTTTGGCCCCGGCTATAGAATTTATTTCATACAAAATGGTGATGAAATCATTGTCTTACTAGCTGGTGGAGATAAATCT
TCACAGCAAAAAGATATTGATAAGGCTATTGAATTAGCAAAAGAAATTCGAGGTGAGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F7HHG5

Antitoxin

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Source
ID
Structure
AlphaFold DBU2NFA4

References