Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2505748..2506318 Replicon chromosome
Accession NZ_CP050154
Organism Brevibacterium sp. o2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GUY37_RS11335 Protein ID WP_166825643.1
Coordinates 2506037..2506318 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GUY37_RS11330 Protein ID WP_166825640.1
Coordinates 2505748..2506050 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY37_RS11305 2501328..2501768 - 441 WP_166825628.1 YtoQ family protein -
GUY37_RS11310 2501920..2503149 - 1230 WP_166825630.1 alpha/beta hydrolase fold domain-containing protein -
GUY37_RS11315 2503351..2503983 - 633 WP_166825633.1 TetR/AcrR family transcriptional regulator -
GUY37_RS11320 2504113..2504967 + 855 WP_166825635.1 SDR family oxidoreductase -
GUY37_RS11325 2505119..2505736 - 618 WP_166825638.1 HAD family hydrolase -
GUY37_RS11330 2505748..2506050 - 303 WP_166825640.1 HigA family addiction module antidote protein Antitoxin
GUY37_RS11335 2506037..2506318 - 282 WP_166825643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUY37_RS11340 2506352..2507437 - 1086 WP_166825646.1 redox-regulated ATPase YchF -
GUY37_RS11345 2507510..2508706 + 1197 WP_166825649.1 DNA recombination protein RmuC -
GUY37_RS11350 2508779..2509795 - 1017 WP_166825652.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
GUY37_RS11355 2509968..2511275 + 1308 WP_166825655.1 exodeoxyribonuclease VII large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10982.47 Da        Isoelectric Point: 10.9902

>T152335 WP_166825643.1 NZ_CP050154:c2506318-2506037 [Brevibacterium sp. o2]
VIRSFGDRATERLWRRERVRSIDPRIHRVALRRLRQVGSAESLEDLRVPPGNRLEALKGDRVGQHSIRINDQWRICFVWT
DAGPEEVQIVDYH

Download         Length: 282 bp

>T152335 NZ_CP066123:1002182-1002460 [Pseudomonas sp. MPFS]
ATGAGACAGCTGAAATGGACGAGCAAGGCGCTATCCGATCTGGCTCGGCTTTTTGAATTTCTCGCTCAGGTTAATCGCTC
GGCTGCTGCTCGGACCGTGCAATCTCTCGTGCGGGCTCCAGATGCGCTGCTATCTAACCCTCGATTGGGAGAGCAGTTGG
AGGAGTTCAAGCCGAAGGATGTTCGACGGTTGCTGGTGGGGCATTACGAGGTGCGTTATGAGATTCAAGGCATGGTCTTG
TCCATCCTGCGTATTTGGCATATCCGGGAAGATCGTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11043.61 Da        Isoelectric Point: 4.8129

>AT152335 WP_166825640.1 NZ_CP050154:c2506050-2505748 [Brevibacterium sp. o2]
MTTTDKIEPIHPGEVLMEDFIEGLGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLVGEQIASIAPLQVS

Download         Length: 303 bp

>AT152335 NZ_CP066123:1001922-1002185 [Pseudomonas sp. MPFS]
ATGCCCGCGACAAAAGTACTGACCGCCCACATTCCCTTGGATCTGGCGGATAAGGTCGATCAACTGGCTTCTCGCCTGGA
GCGCTCCCGTGCCTGGATCGTGAAGCAAGCATTGGTAGCCTGGGTTGACCAGGAAGAAGAGCGCCGCCGACTGACGCTTG
AGGCCTTGGCAGATGTCGATGCTGGAAGGGTTGTCGATCATCAGTCCGTGCTGGCTTGGGCAGAGAGTCTGTCTGGCGAC
AACCCTCTGCCTTTACCAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References