Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1487525..1488095 Replicon chromosome
Accession NZ_CP050153
Organism Brevibacterium sp. YB235

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GUY30_RS06630 Protein ID WP_167195294.1
Coordinates 1487525..1487806 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GUY30_RS06635 Protein ID WP_167195297.1
Coordinates 1487793..1488095 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY30_RS06620 1483229..1483612 + 384 WP_167195291.1 hypothetical protein -
GUY30_RS06625 1485059..1487416 + 2358 WP_167200760.1 hypothetical protein -
GUY30_RS06630 1487525..1487806 + 282 WP_167195294.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUY30_RS06635 1487793..1488095 + 303 WP_167195297.1 HigA family addiction module antidote protein Antitoxin
GUY30_RS06640 1488092..1488250 + 159 WP_167195300.1 phosphotransferase -
GUY30_RS06645 1488537..1489130 + 594 WP_167195303.1 ArsR family transcriptional regulator -
GUY30_RS06650 1489123..1489563 + 441 WP_167195306.1 HEPN domain-containing protein -
GUY30_RS06655 1489589..1489773 + 185 Protein_1305 DUF933 domain-containing protein -
GUY30_RS06660 1490227..1491267 - 1041 WP_167195309.1 methionine synthase -
GUY30_RS06665 1491285..1492277 - 993 WP_167195312.1 DUF1852 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1484954..1496713 11759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10940.57 Da        Isoelectric Point: 11.2350

>T152332 WP_167195294.1 NZ_CP050153:1487525-1487806 [Brevibacterium sp. YB235]
MIRSFGDKERERLWHRGRVRSIGPRIHRVALRKLRQVGSAEVLEDLRVPSGNRLEALKGERAGQHIIRINDQWRICFVRT
EAGPEEVEIVDYR

Download         Length: 282 bp

>T152332 NZ_CP066123:564559-564855 [Pseudomonas sp. MPFS]
ATGCATATCATCACCGCAAAACGCATCTGGCAGGCCAAGGAGCAGTGGCCGCAGACCGCACGAGCGCTGGATACCTGGTA
TCGCAAGGCCAAGGGCGCCAGGCCAGAGGACTTTTCCGATATGAAGGCGTTGTTTCCGGCGGTCGATAAGGTCGGGCGCT
TCCATGTCTTCGACATCGGCGGCAACAAGCTGAGGTTGATCGCCCTGGTGCGCTATGGAGTCCAGCGGCTCTACATCAGG
CATGTATTGGACCACGCCAGCTACGACAAGGGGCTGTGGAAGGAGGAAATAGAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.60 Da        Isoelectric Point: 4.4901

>AT152332 WP_167195297.1 NZ_CP050153:1487793-1488095 [Brevibacterium sp. YB235]
MTTADEIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWMNLQSHYEL
DRAEDQAGEQIASIVPLQVV

Download         Length: 303 bp

>AT152332 NZ_CP066123:564852-565253 [Pseudomonas sp. MPFS]
ATGAGCGTACTGGTCAGCCAGGCGGCGGAGCACTGGCAATTCGTCGCGCCGCTGCTGCGCAAGCCCAGGACTGAGGCCGA
TTACGATGCTCTGGCCCTGGCCCTGGATGAATTGCTGGACATCATGGGCGAGGATGAGGCTCATCCGCTGGCCTCACTGG
TGGACATCATCGGTGATTGGATCGAGGCCTATGACGAAGAGCATCGGCCGATACCTCCCGTCAGTGGCGTGGAGGTCTTG
CGCTCGTTGATGCACGAGCACGGCCTGACCCAGAGCGACCTGCCCGGGGTCGGGGCGCAATCGGTGGTTTCCGAAGTGCT
GAGTGGCAAGCGCCAGCTCAACCTGCGGCAGGTGCGCTGGCTGTCCGAGCGCTTCAAGGTGGCAATGGAGGTGTTCGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References