Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1704706..1705276 Replicon chromosome
Accession NZ_CP050152
Organism Brevibacterium sp. WO024

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GUY23_RS07480 Protein ID WP_166971094.1
Coordinates 1704706..1704987 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GUY23_RS07485 Protein ID WP_166971096.1
Coordinates 1704974..1705276 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY23_RS07455 1700932..1702125 - 1194 WP_166971085.1 DNA recombination protein RmuC -
GUY23_RS07460 1702198..1703283 + 1086 WP_166971087.1 redox-regulated ATPase YchF -
GUY23_RS07465 1703409..1703642 + 234 WP_166971088.1 Arc family DNA-binding protein -
GUY23_RS07470 1703639..1704064 + 426 WP_166971090.1 type II toxin-antitoxin system VapC family toxin -
GUY23_RS07475 1704046..1704612 + 567 WP_166971092.1 GNAT family N-acetyltransferase -
GUY23_RS07480 1704706..1704987 + 282 WP_166971094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUY23_RS07485 1704974..1705276 + 303 WP_166971096.1 HigA family addiction module antidote protein Antitoxin
GUY23_RS07490 1705306..1706022 + 717 WP_166975777.1 phosphotransferase -
GUY23_RS07495 1706045..1706638 + 594 WP_166971098.1 ArsR family transcriptional regulator -
GUY23_RS07500 1706797..1707052 + 256 Protein_1473 DUF933 domain-containing protein -
GUY23_RS07505 1707227..1708267 - 1041 WP_166971100.1 methionine synthase -
GUY23_RS07510 1708285..1709277 - 993 WP_166971102.1 DUF1852 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10810.22 Da        Isoelectric Point: 9.0809

>T152331 WP_166971094.1 NZ_CP050152:1704706-1704987 [Brevibacterium sp. WO024]
VIRSFGDKATERLWRRERVRSIDPRIHRVALRKLLQAGSAEPLEDLRNPPGNRLEALKGDRAGQYSIRINDQWRVCITWT
DAGPEEVEIVDYN

Download         Length: 282 bp

>T152331 NZ_CP066123:188427-188708 [Pseudomonas sp. MPFS]
ATGACTTATAAACTCGAGTTCCTGCCTTCGGCGCTCAAGGAGTGGAACAAGCTGGGCCATACGCTTCGCGAGCAATTCAA
GAAGAAGCTCGCGCAACGGCTGCAAATGCCCCAAGTCCCAGCAGATGCCCTGTACGGTTTACCCGACTGCTACAAGATCA
AGCTCAAGGCCTCGGGTTATCGGCTGGTCTATAAGGTTATCGAGCAGCGCGTTGTGGTGGCTGTTGTCGCGGTCGGTAAG
CGCGAGCGCGGGGCTGTGTACGAGCAAGCCAGGAAGCGTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11104.61 Da        Isoelectric Point: 4.8129

>AT152331 WP_166971096.1 NZ_CP050152:1704974-1705276 [Brevibacterium sp. WO024]
MTTTDRIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDQAGEQIASIVPLQVA

Download         Length: 303 bp

>AT152331 NZ_CP066123:188192-188437 [Pseudomonas sp. MPFS]
ATGCAAAGTATCCTGGCTGACAAAGCCGTCAGCGTATCTGAATTGAAGAAGAATCCTTCAGCGGTATTGAACGGCGCTCA
AGGTGGCCCGGTGGCTGTGTTGAACCACAACCGGGTCATGGGCTACATGATTCCTGCCGAAGTTTTCGAAGCGTTGATGG
AGCGTTTGGACGATCTGGAACTGGCCGAGATCGTTCGGGCGCGTAGTCAGGAGACTCCCGTCCCGGTCAGTCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References