Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1323111..1323626 Replicon chromosome
Accession NZ_CP050152
Organism Brevibacterium sp. WO024

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GUY23_RS05765 Protein ID WP_166970523.1
Coordinates 1323372..1323626 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GUY23_RS05760 Protein ID WP_166970521.1
Coordinates 1323111..1323371 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY23_RS05740 1318590..1320083 - 1494 WP_166970515.1 esterase family protein -
GUY23_RS05745 1320161..1321768 + 1608 WP_166975686.1 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase -
GUY23_RS05750 1321781..1322143 - 363 WP_166970517.1 MerR family DNA-binding protein -
GUY23_RS05755 1322207..1323046 + 840 WP_166970519.1 NAD(P)H-binding protein -
GUY23_RS05760 1323111..1323371 + 261 WP_166970521.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GUY23_RS05765 1323372..1323626 + 255 WP_166970523.1 Txe/YoeB family addiction module toxin Toxin
GUY23_RS05770 1323838..1324761 - 924 WP_166970525.1 hypothetical protein -
GUY23_RS05775 1324758..1326122 - 1365 WP_166970527.1 isochorismate synthase -
GUY23_RS05780 1326305..1326997 + 693 WP_166970529.1 demethylmenaquinone methyltransferase -
GUY23_RS05785 1326994..1328295 + 1302 WP_166970531.1 geranylgeranyl reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10015.39 Da        Isoelectric Point: 7.2746

>T152329 WP_166970523.1 NZ_CP050152:1323372-1323626 [Brevibacterium sp. WO024]
VRLVWDQSAWEDYKHWQTADRKILKRIDTLVDACLREPFSGIGKPEQLKYGAQGAWSRRITDEHRLVYLVVDDDLVILQA
RYHY

Download         Length: 255 bp

>T152329 NZ_CP066122:c79212-78922 [Acinetobacter bereziniae]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCGCTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAAAATGATCCAGCTGAATTAGCCCATGCACTTGGTGTTATTGCTAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGGCGTGAAGCACTCTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCTTTAGGCTTAAAGCTCACAGTACAACACGCTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9665.84 Da        Isoelectric Point: 5.8631

>AT152329 WP_166970521.1 NZ_CP050152:1323111-1323371 [Brevibacterium sp. WO024]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARGGKVEVHDLD
RSDKEA

Download         Length: 261 bp

>AT152329 NZ_CP066122:c79510-79214 [Acinetobacter bereziniae]
ATGATTGAAATTAAACGTCTTCCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGTATCCGCCTGAA
TCGTCGATTAGATAAGGTTCAACGTGGAAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGGGCAGTCAAACTATCGAAAACATTGGAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References