Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4010078..4010805 Replicon chromosome
Accession NZ_CP050150
Organism Hafnia alvei strain A23BA

Toxin (Protein)


Gene name higB Uniprot ID A0A377PNS5
Locus tag HBA19_RS18385 Protein ID WP_043489169.1
Coordinates 4010078..4010389 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A377PPD5
Locus tag HBA19_RS18390 Protein ID WP_043489166.1
Coordinates 4010386..4010805 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA19_RS18375 4007576..4008487 - 912 WP_043489174.1 transcriptional regulator FeaR -
HBA19_RS18380 4008623..4009723 - 1101 WP_166493634.1 DUF1615 domain-containing protein -
HBA19_RS18385 4010078..4010389 + 312 WP_043489169.1 type II toxin-antitoxin system HigB family toxin Toxin
HBA19_RS18390 4010386..4010805 + 420 WP_043489166.1 helix-turn-helix domain-containing protein Antitoxin
HBA19_RS18395 4010890..4011573 - 684 WP_166493635.1 hypothetical protein -
HBA19_RS18400 4011566..4012600 - 1035 WP_038503035.1 StbA family protein -
HBA19_RS18405 4013275..4014057 - 783 WP_043489162.1 crotonobetainyl-CoA hydratase -
HBA19_RS18410 4014072..4015643 - 1572 WP_166493636.1 crotonobetaine/carnitine-CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12468.25 Da        Isoelectric Point: 9.7852

>T152325 WP_043489169.1 NZ_CP050150:4010078-4010389 [Hafnia alvei]
MHIISRDPFEDAARKYPNDAASLIAAYRLLKENEFESPAELRKLFPNLDNFKYRNKWWVINIGGNNLRMISYINFVNQRF
YVKHIVTHAEYDKLTRQYREIKE

Download         Length: 312 bp

>T152325 NZ_CP066122:c70077-69757 [Acinetobacter bereziniae]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15474.70 Da        Isoelectric Point: 4.5542

>AT152325 WP_043489166.1 NZ_CP050150:4010386-4010805 [Hafnia alvei]
MILEPTKALEAAKVLADAVPFLGGNTSEEAYRDALAMVDYLIEHDDESPLIDFLALKIAEYEDNNERFKAFNQAVTDMPT
GVAALRVLIEQHQLSYSDLASEIGSKSLVSMILSGKRSLTIEHIKALSKRFNVRPDLFF

Download         Length: 420 bp

>AT152325 NZ_CP066122:c69764-69492 [Acinetobacter bereziniae]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377PNS5

Antitoxin

Source ID Structure
AlphaFold DB A0A377PPD5

References