Detailed information of TA system TA152266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2158988..2159577
• Replicon: chromosome
• Accession: NZ_CP050115
• Organism: Xanthomonas oryzae pv. oryzae strain K3a

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A8E2YMU3
• Locus tag: HAQ11_RS10160
• Protein ID: WP_011260747.1
• Coordinates: 2158988..2159269 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HAQ11_RS10165
• Protein ID: WP_011260746.1
• Coordinates: 2159287..2159577 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAQ11_RS10155	2156641..2158893	+	2253	WP_011409750.1	exodeoxyribonuclease V subunit alpha	-
HAQ11_RS10160	2158988..2159269	+	282	WP_011260747.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HAQ11_RS10165	2159287..2159577	+	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
HAQ11_RS10170	2160515..2161909	+	1395	WP_027703652.1	nucleoside hydrolase	-
HAQ11_RS10175	2162359..2162691	-	333	WP_011260743.1	hypothetical protein	-
HAQ11_RS10180	2163027..2163272	+	246	WP_069960049.1	hypothetical protein	-
HAQ11_RS10185	2163388..2163822	+	435	WP_011409747.1	PAAR domain-containing protein	-
HAQ11_RS10190	2163825..2164298	+	474	Protein_1939	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11070.83 Da
• Isoelectric Point: 10.2139

>T152266 WP_011260747.1 NZ_CP050115:2158988-2159269 [Xanthomonas oryzae pv. oryzae]
MIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQQRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T152266 NZ_CP066085:c3384067-3383789 [Escherichia fergusonii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGTGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT152266 WP_011260746.1 NZ_CP050115:2159287-2159577 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT152266 NZ_CP066085:c3383789-3383505 [Escherichia fergusonii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCCGCGTTGACGCCAGAAATGGCGA
TTAAACTTTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTACAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA