Detailed information of TA system TA152263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2315454..2316043
• Replicon: chromosome
• Accession: NZ_CP050114
• Organism: Xanthomonas oryzae pv. oryzae strain K3

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A8E2YMU3
• Locus tag: HAQ10_RS10850
• Protein ID: WP_011260747.1
• Coordinates: 2315762..2316043 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HAQ10_RS10845
• Protein ID: WP_011260746.1
• Coordinates: 2315454..2315744 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAQ10_RS10820	2310733..2311206	-	474	Protein_2057	DUF4123 domain-containing protein	-
HAQ10_RS10825	2311209..2311643	-	435	WP_011409747.1	PAAR domain-containing protein	-
HAQ10_RS10830	2311759..2312004	-	246	WP_069960049.1	hypothetical protein	-
HAQ10_RS10835	2312340..2312672	+	333	WP_011260743.1	hypothetical protein	-
HAQ10_RS10840	2313122..2314516	-	1395	WP_027703652.1	nucleoside hydrolase	-
HAQ10_RS10845	2315454..2315744	-	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
HAQ10_RS10850	2315762..2316043	-	282	WP_011260747.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HAQ10_RS10855	2316138..2318390	-	2253	WP_011409750.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11070.83 Da
• Isoelectric Point: 10.2139

>T152263 WP_011260747.1 NZ_CP050114:c2316043-2315762 [Xanthomonas oryzae pv. oryzae]
MIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQQRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T152263 NZ_CP066085:2152665-2153000 [Escherichia fergusonii]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGATCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTGAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT152263 WP_011260746.1 NZ_CP050114:c2315744-2315454 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT152263 NZ_CP066085:2152417-2152665 [Escherichia fergusonii]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA