Detailed information of TA system TA152194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1202878..1203527
• Replicon: chromosome
• Accession: NZ_CP050073
• Organism: Enterobacter kobei strain 070

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HA514_RS05870
• Protein ID: WP_121527586.1
• Coordinates: 1203165..1203527 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HA514_RS05865
• Protein ID: WP_045134924.1
• Coordinates: 1202878..1203177 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA514_RS05855	1199303..1201276	+	1974	WP_121527584.1	PhoX family phosphatase	-
HA514_RS05860	1201379..1202767	+	1389	WP_121527585.1	phenylalanine transporter	-
HA514_RS05865	1202878..1203177	-	300	WP_045134924.1	helix-turn-helix transcriptional regulator	Antitoxin
HA514_RS05870	1203165..1203527	-	363	WP_121527586.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HA514_RS05875	1203733..1204968	+	1236	WP_121527587.1	MFS transporter	-
HA514_RS05880	1204984..1206009	+	1026	WP_121527588.1	sugar phosphate isomerase/epimerase	-
HA514_RS05885	1206002..1207144	+	1143	WP_121527589.1	Gfo/Idh/MocA family oxidoreductase	-
HA514_RS05890	1207220..1208191	+	972	WP_045281665.1	LacI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-87)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13983.93 Da
• Isoelectric Point: 6.2260

>T152194 WP_121527586.1 NZ_CP050073:c1203527-1203165 [Enterobacter kobei]
MWNVETTDRFDQWYFEQTTALKEDVLTMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Nucleotide

• Length: 363 bp

>T152194 NZ_CP066032:3485957-3486060 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10890.64 Da
• Isoelectric Point: 9.8627

>AT152194 WP_045134924.1 NZ_CP050073:c1203177-1202878 [Enterobacter kobei]
MATLKELMAQQSTESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Nucleotide

• Length: 300 bp

>AT152194 NZ_CP066032:c3486061-3485827 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT