Detailed information of TA system TA152101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 776520..777213
• Replicon: chromosome
• Accession: NZ_CP050044
• Organism: Escherichia coli strain 74-2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: G9P51_RS03685
• Protein ID: WP_000415584.1
• Coordinates: 776520..776816 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: G9P51_RS03690
• Protein ID: WP_130553696.1
• Coordinates: 776818..777213 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9P51_RS03660	771807..772388	-	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
G9P51_RS03665	772707..773039	+	333	WP_000917684.1	DUF2645 family protein	-
G9P51_RS03670	773085..774434	-	1350	WP_000673402.1	two-component system sensor histidine kinase QseC	-
G9P51_RS03675	774431..775090	-	660	WP_130553695.1	two-component system response regulator QseB	-
G9P51_RS03680	775316..776284	+	969	WP_000654811.1	IS5 family transposase	-
G9P51_RS03685	776520..776816	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
G9P51_RS03690	776818..777213	+	396	WP_130553696.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
G9P51_RS03695	777346..778953	+	1608	Protein_724	ABC transporter substrate-binding protein	-
G9P51_RS03700	779091..781349	+	2259	WP_001281881.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	775361..776284	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T152101 WP_000415584.1 NZ_CP050044:776520-776816 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T152101 NZ_CP065966:c2287227-2286928 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14675.05 Da
• Isoelectric Point: 9.2136

>AT152101 WP_130553696.1 NZ_CP050044:776818-777213 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCAHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT152101 NZ_CP065966:c2286931-2286641 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Structures

Toxin

• PDB: 3HI2