Detailed information of TA system TA152069

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2657267..2657487
• Replicon: chromosome
• Accession: NZ_CP050036
• Organism: Escherichia coli strain 58-3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: G9P49_RS12880
• Protein ID: WP_000170963.1
• Coordinates: 2657380..2657487 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2657267..2657333 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9P49_RS12855	2653590..2653943	+	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-
G9P49_RS12860	2653987..2654682	-	696	WP_001297117.1	glutathione-specific gamma-glutamylcyclotransferase	-
G9P49_RS12865	2654840..2655070	-	231	WP_001146444.1	putative cation transport regulator ChaB	-
G9P49_RS12870	2655340..2656440	+	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
-	2656730..2656797	-	68	NuclAT_27	-	-
-	2656730..2656797	-	68	NuclAT_27	-	-
-	2656730..2656797	-	68	NuclAT_27	-	-
-	2656730..2656797	-	68	NuclAT_27	-	-
-	2656730..2656797	-	68	NuclAT_29	-	-
-	2656730..2656797	-	68	NuclAT_29	-	-
-	2656730..2656797	-	68	NuclAT_29	-	-
-	2656730..2656797	-	68	NuclAT_29	-	-
-	2656730..2656797	-	68	NuclAT_31	-	-
-	2656730..2656797	-	68	NuclAT_31	-	-
-	2656730..2656797	-	68	NuclAT_31	-	-
-	2656730..2656797	-	68	NuclAT_31	-	-
-	2656730..2656797	-	68	NuclAT_33	-	-
-	2656730..2656797	-	68	NuclAT_33	-	-
-	2656730..2656797	-	68	NuclAT_33	-	-
-	2656730..2656797	-	68	NuclAT_33	-	-
-	2656730..2656797	-	68	NuclAT_35	-	-
-	2656730..2656797	-	68	NuclAT_35	-	-
-	2656730..2656797	-	68	NuclAT_35	-	-
-	2656730..2656797	-	68	NuclAT_35	-	-
-	2656730..2656797	-	68	NuclAT_37	-	-
-	2656730..2656797	-	68	NuclAT_37	-	-
-	2656730..2656797	-	68	NuclAT_37	-	-
-	2656730..2656797	-	68	NuclAT_37	-	-
-	2656732..2656797	-	66	NuclAT_14	-	-
-	2656732..2656797	-	66	NuclAT_14	-	-
-	2656732..2656797	-	66	NuclAT_14	-	-
-	2656732..2656797	-	66	NuclAT_14	-	-
-	2656732..2656797	-	66	NuclAT_16	-	-
-	2656732..2656797	-	66	NuclAT_16	-	-
-	2656732..2656797	-	66	NuclAT_16	-	-
-	2656732..2656797	-	66	NuclAT_16	-	-
-	2656732..2656797	-	66	NuclAT_18	-	-
-	2656732..2656797	-	66	NuclAT_18	-	-
-	2656732..2656797	-	66	NuclAT_18	-	-
-	2656732..2656797	-	66	NuclAT_18	-	-
-	2656732..2656797	-	66	NuclAT_20	-	-
-	2656732..2656797	-	66	NuclAT_20	-	-
-	2656732..2656797	-	66	NuclAT_20	-	-
-	2656732..2656797	-	66	NuclAT_20	-	-
-	2656732..2656797	-	66	NuclAT_23	-	-
-	2656732..2656797	-	66	NuclAT_23	-	-
-	2656732..2656797	-	66	NuclAT_23	-	-
-	2656732..2656797	-	66	NuclAT_23	-	-
-	2656732..2656797	-	66	NuclAT_25	-	-
-	2656732..2656797	-	66	NuclAT_25	-	-
-	2656732..2656797	-	66	NuclAT_25	-	-
-	2656732..2656797	-	66	NuclAT_25	-	-
G9P49_RS12875	2656845..2656952	+	108	WP_000170965.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	2657267..2657333	-	67	-	-	Antitoxin
G9P49_RS12880	2657380..2657487	+	108	WP_000170963.1	small toxic polypeptide LdrB	Toxin
G9P49_RS12885	2657634..2658488	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
G9P49_RS12890	2658524..2659333	-	810	WP_001257044.1	invasion regulator SirB1	-
G9P49_RS12895	2659337..2659729	-	393	WP_001409175.1	invasion regulator SirB2	-
G9P49_RS12900	2659726..2660559	-	834	WP_032177158.1	peptide chain release factor N(5)-glutamine methyltransferase	-
G9P49_RS12905	2660559..2661641	-	1083	WP_000804726.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T152069 WP_000170963.1 NZ_CP050036:2657380-2657487 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T152069 NZ_CP065947:c5174742-5174164 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTACTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT152069 NZ_CP050036:c2657333-2657267 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin