Detailed information of TA system TA152068

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2656732..2656952
• Replicon: chromosome
• Accession: NZ_CP050036
• Organism: Escherichia coli strain 58-3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: B7LGX8
• Locus tag: G9P49_RS12875
• Protein ID: WP_000170965.1
• Coordinates: 2656845..2656952 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2656732..2656798 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9P49_RS12850	2652010..2653404	-	1395	WP_001400233.1	inverse autotransporter invasin YchO	-
G9P49_RS12855	2653590..2653943	+	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-
G9P49_RS12860	2653987..2654682	-	696	WP_001297117.1	glutathione-specific gamma-glutamylcyclotransferase	-
G9P49_RS12865	2654840..2655070	-	231	WP_001146444.1	putative cation transport regulator ChaB	-
G9P49_RS12870	2655340..2656440	+	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
-	2656732..2656798	-	67	-	-	Antitoxin
G9P49_RS12875	2656845..2656952	+	108	WP_000170965.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2657265..2657332	-	68	NuclAT_26	-	-
-	2657265..2657332	-	68	NuclAT_26	-	-
-	2657265..2657332	-	68	NuclAT_26	-	-
-	2657265..2657332	-	68	NuclAT_26	-	-
-	2657265..2657332	-	68	NuclAT_28	-	-
-	2657265..2657332	-	68	NuclAT_28	-	-
-	2657265..2657332	-	68	NuclAT_28	-	-
-	2657265..2657332	-	68	NuclAT_28	-	-
-	2657265..2657332	-	68	NuclAT_30	-	-
-	2657265..2657332	-	68	NuclAT_30	-	-
-	2657265..2657332	-	68	NuclAT_30	-	-
-	2657265..2657332	-	68	NuclAT_30	-	-
-	2657265..2657332	-	68	NuclAT_32	-	-
-	2657265..2657332	-	68	NuclAT_32	-	-
-	2657265..2657332	-	68	NuclAT_32	-	-
-	2657265..2657332	-	68	NuclAT_32	-	-
-	2657265..2657332	-	68	NuclAT_34	-	-
-	2657265..2657332	-	68	NuclAT_34	-	-
-	2657265..2657332	-	68	NuclAT_34	-	-
-	2657265..2657332	-	68	NuclAT_34	-	-
-	2657265..2657332	-	68	NuclAT_36	-	-
-	2657265..2657332	-	68	NuclAT_36	-	-
-	2657265..2657332	-	68	NuclAT_36	-	-
-	2657265..2657332	-	68	NuclAT_36	-	-
-	2657267..2657332	-	66	NuclAT_13	-	-
-	2657267..2657332	-	66	NuclAT_13	-	-
-	2657267..2657332	-	66	NuclAT_13	-	-
-	2657267..2657332	-	66	NuclAT_13	-	-
-	2657267..2657332	-	66	NuclAT_15	-	-
-	2657267..2657332	-	66	NuclAT_15	-	-
-	2657267..2657332	-	66	NuclAT_15	-	-
-	2657267..2657332	-	66	NuclAT_15	-	-
-	2657267..2657332	-	66	NuclAT_17	-	-
-	2657267..2657332	-	66	NuclAT_17	-	-
-	2657267..2657332	-	66	NuclAT_17	-	-
-	2657267..2657332	-	66	NuclAT_17	-	-
-	2657267..2657332	-	66	NuclAT_19	-	-
-	2657267..2657332	-	66	NuclAT_19	-	-
-	2657267..2657332	-	66	NuclAT_19	-	-
-	2657267..2657332	-	66	NuclAT_19	-	-
-	2657267..2657332	-	66	NuclAT_22	-	-
-	2657267..2657332	-	66	NuclAT_22	-	-
-	2657267..2657332	-	66	NuclAT_22	-	-
-	2657267..2657332	-	66	NuclAT_22	-	-
-	2657267..2657332	-	66	NuclAT_24	-	-
-	2657267..2657332	-	66	NuclAT_24	-	-
-	2657267..2657332	-	66	NuclAT_24	-	-
-	2657267..2657332	-	66	NuclAT_24	-	-
G9P49_RS12880	2657380..2657487	+	108	WP_000170963.1	small toxic polypeptide LdrB	-
G9P49_RS12885	2657634..2658488	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
G9P49_RS12890	2658524..2659333	-	810	WP_001257044.1	invasion regulator SirB1	-
G9P49_RS12895	2659337..2659729	-	393	WP_001409175.1	invasion regulator SirB2	-
G9P49_RS12900	2659726..2660559	-	834	WP_032177158.1	peptide chain release factor N(5)-glutamine methyltransferase	-
G9P49_RS12905	2660559..2661641	-	1083	WP_000804726.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4001.77 Da
• Isoelectric Point: 11.4779

>T152068 WP_000170965.1 NZ_CP050036:2656845-2656952 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T152068 NZ_CP065947:4178528-4179283 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATGCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT152068 NZ_CP050036:c2656798-2656732 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGTGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y029

Antitoxin